International Journal of Clinical Pharmacy

, Volume 40, Issue 5, pp 1359–1371 | Cite as

Epidemiology of drug hypersensitivity reactions using 6-year national health insurance claim data from Korea

  • JaeEun Han
  • Young-Min Ye
  • Sukhyang LeeEmail author
Research Article


Background Drug hypersensitivity reactions (DHRs) constitute a large portion of adverse drug reactions (ADRs), but studies for DHR incidence based on national data are scarce. Objective This study aimed to estimate the incidence and patterns of DHRs in a Korean population and the associated utilization of medical resources using the national claims data. Setting The retrospective cohort study performed using the national insurance claim database of the Health Insurance Review and Assessment (HIRA) in Korea. Methods The International Classification of Disease 10th revision code was used to identify DHRs with 20 drug induced DHR codes. The claim data with a diagnosis of DHR in the 2009-2014 periods were analyzed. Main outcome and measure The annual incidence and the 6-year incidence rates were calculated. Incidence rate coefficients were analyzed by sex, age, and year. DHRs following with visits of emergency department (ED) or intensive care unit (ICU) were assessed for utilization of medical resources and risk of ER or ICU visits by sex and age Results A total of 535,049 patients with 1,083,507 claims were assessed in the HIRA database for 6 years. DHR incidence was high in the elderly. The risk of ED and ICU visit with DHR was also higher in the elderly than in the young [highest relative risk, RR of ED 2.59 (1.65–4.07), ICU 5.04 (2.50–10.18)]. DHRs related to blood were high in the young age. Conclusion Incidence of DHRs in the real-world clinical practice was higher in the elderly and female. Clinical consequence was more severe in the elderly.


Adverse drug reactions (ADRs) Drug hypersensitivity Health insurance database Incidence Korea 



This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT & Future Planning, Republic of Korea (No. 2013M3A9B5075838).

Conflicts of interest

The authors have no conflicts of interest that are directly relevant to the content of this study.

Supplementary material

11096_2018_625_MOESM1_ESM.pdf (139 kb)
Supplementary material 1 (PDF 139 kb)
11096_2018_625_MOESM2_ESM.pdf (164 kb)
Supplementary material 2 (PDF 163 kb)


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Clinical PharmacyCollege of Pharmacy, Ajou UniversitySuwonRepublic of Korea
  2. 2.Department of PharmacyAjou University HospitalSuwonRepublic of Korea
  3. 3.Department of AllergyCollege of Medicine, Ajou UniversitySuwonRepublic of Korea
  4. 4.Division of Clinical Pharmacy Practice EducationAjou University HospitalSuwonRepublic of Korea

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