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International Journal of Clinical Pharmacy

, Volume 40, Issue 2, pp 345–353 | Cite as

Efficacy of a telephone-based intervention among patients with type-2 diabetes; a randomized controlled trial in pharmacy practice

  • Amir Sarayani
  • Mojgan Mashayekhi
  • Marzieh Nosrati
  • Zahra Jahangard-Rafsanjani
  • Mohammadreza Javadi
  • Navid Saadat
  • Sheyda Najafi
  • Kheirollah Gholami
Research Article
  • 274 Downloads

Abstract

Background Pharmacists’ interventions to improve outcomes of diabetes management have been promising. However, evidence on using telephone-based interventions in pharmacy practice are limited, particularly in developing countries. Objective To evaluate the efficacy of a telephone-based intervention to improve care and clinical outcomes in type-2 diabetes. Setting A referral community pharmacy and drug information center. Method We conducted a two-armed randomized controlled trial on 100 patients with type-2 diabetes. The intervention consisted of 16 telephone calls in 3 month by a trained pharmacist working in an academic drug information center, while the control group received usual care. Before random allocation, patients attended a live education session delivered by pharmacists to learn the basics of diabetes care and to confirm the eligibility criteria. Assessments were performed at baseline, month-3 (after intervention), and month-9 (follow-up). Main outcome measure Hemoglobin A1c (HbA1c). Results Eighty four patient completed the trial. Baseline variables were comparable between the two groups and the baseline value of hemoglobin A1c was 8.00 ± 1.44 in the study population. HbA1c was significantly improved in both groups at month-3 (6.97 ± 1.41 vs. 7.09 ± 1.78) and remained steady at month-9 (6.96 ± 1.44 vs. 7.26 ± 1.85). Lipid profile showed small improvements in the intervention group but was not significant. The adherence score and self-care score improvement was significantly higher in the intervention group at month-3 and were maintained at month-9. Conclusion Medication adherence and self-care significantly improved in the telephone-based intervention group. However, the improvement of clinical outcomes might have been diluted due to the live diabetes education session.

Keywords

Diabetes education Diabetes Type-2 HbA1c Iran Medication adherence Pharmacist Self-care Telephone counseling 

Notes

Acknowledgements

We would like to thank Dr. Kazem Heydari for his help in data analysis and Ms. Saba Afjei for coordinating the recruitment process, the educational sessions, and laboratory test schedule. We also appreciate Brianna Costales’ assistance preparing the final revision of the manuscript.

Funding

This study was supported by a research grant from Research Deputy of Tehran University of Medical Sciences (ID: 91-03-156-19496).

Conflicts of interests

We have no conflicts of financial interest to declare. The study was conducted by a team of community pharmacists and clinical pharmacists.

Supplementary material

11096_2018_593_MOESM1_ESM.doc (218 kb)
Consortchecklist (DOC 218 kb)

References

  1. 1.
    Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, et al. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40–50.CrossRefPubMedGoogle Scholar
  2. 2.
    Menke A, Rust KF, Fradkin J, Cheng YJ, Cowie CC. Associations between trends in race/ethnicity, aging, and body mass index with diabetes prevalence in the United States: a series of cross-sectional studies. Ann Intern Med. 2014;161(5):328–35.CrossRefPubMedGoogle Scholar
  3. 3.
    Hu H, Hori A, Nishiura C, Sasaki N, Okazaki H, Nakagawa T, et al. Hba1c, blood pressure, and lipid control in people with diabetes: Japan epidemiology collaboration on occupational health study. PLoS ONE. 2016;11(7):e0159071.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Stark Casagrande S, Fradkin JE, Saydah SH, Rust KF, Cowie CC. The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988-2010. Diabetes Care. 2013;36(8):2271–9.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Feldman BS, Cohen-Stavi CJ, Leibowitz M, Hoshen MB, Singer SR, Bitterman H, et al. Defining the role of medication adherence in poor glycemic control among a general adult population with diabetes. PLoS ONE. 2014;9(9):e108145.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Sarayani A, Jahangard-Rafsanjani Z, Hadjibabaie M, Ahmadvand A, Javadi M, Gholami K. A comprehensive review of adherence to diabetes and cardiovascular medications in Iran; implications for practice and research. J Diabetes Metab Disord. 2013;12(1):57.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Paduch A, Kuske S, Schiereck T, Droste S, Loerbroks A, Sørensen M, et al. Psychosocial barriers to healthcare use among individuals with diabetes mellitus: a systematic review. Prim Care Diabetes. 2017;11(6):495–514.CrossRefPubMedGoogle Scholar
  8. 8.
    Singh K, Ranjani H, Rhodes E, Weber MB. International models of care that address the growing diabetes prevalence in developing countries. Curr Diab Rep. 2016;16(8):69.CrossRefPubMedGoogle Scholar
  9. 9.
    Wubben DP, Vivian EM. Effects of pharmacist outpatient interventions on adults with diabetes mellitus: a systematic review. Pharmacotherapy. 2008;28(4):421–36.CrossRefPubMedGoogle Scholar
  10. 10.
    Rothman R, Malone R, Bryant B, Horlen C, Pignone M. Pharmacist-led, primary care-based disease management improves hemoglobin A1c in high-risk patients with diabetes. Am J Med Qual. 2003;18(2):51–8.CrossRefPubMedGoogle Scholar
  11. 11.
    Clifford RM, Davis WA, Batty KT, Davis TM. Effect of a pharmaceutical care program on vascular risk factors in type 2 diabetes: the Fremantle Diabetes Study. Diabetes Care. 2005;28(4):771–6.CrossRefPubMedGoogle Scholar
  12. 12.
    Farsaei S, Sabzghabaee AM, Zargarzadeh AH, Amini M. Effect of pharmacist-led patient education on glycemic control of type 2 diabetics: a randomized controlled trial. J Res Med Sci. 2011;16(1):43–9.PubMedPubMedCentralGoogle Scholar
  13. 13.
    Armor BL, Britton ML, Dennis VC, Letassy NA. A review of pharmacist contributions to diabetes care in the United States. J Pharm Pract. 2010;23(3):250–64.CrossRefPubMedGoogle Scholar
  14. 14.
    Jahangard-Rafsanjani Z, Sarayani A, Nosrati M, Saadat N, Rashidian A, Hadjibabaie M, et al. Effect of a community pharmacist-delivered diabetes support program for patients receiving specialty medical care: a randomized controlled trial. Diabetes Educ. 2015;41(1):127–35.CrossRefPubMedGoogle Scholar
  15. 15.
    Collins C, Limone BL, Scholle JM, Coleman CI. Effect of pharmacist intervention on glycemic control in diabetes. Diabetes Res Clin Pract. 2011;92(2):145–52.CrossRefPubMedGoogle Scholar
  16. 16.
    Pande S, Hiller JE, Nkansah N, Bero L. The effect of pharmacist-provided non-dispensing services on patient outcomes, health service utilisation and costs in low- and middle-income countries. Cochrane Database Syst Rev. 2013;2:CD010398.Google Scholar
  17. 17.
    Angaran DM. Telemedicine and telepharmacy: current status and future implications. Am J Health Syst Pharm. 1999;56(14):1405–26.PubMedGoogle Scholar
  18. 18.
    Harris JE, Chen TC, Kim SB, Nguyen KL. Development of a pharmacist-managed, telephone-based tobacco-cessation clinic for veterans. Am J Health Syst Pharm. 2009;66(18):1610.CrossRefPubMedGoogle Scholar
  19. 19.
    Hailey D, Roine R, Ohinmaa A. Systematic review of evidence for the benefits of telemedicine. J Telemed Telecare. 2002;8(suppl 1):1–7.PubMedGoogle Scholar
  20. 20.
    Whitten PS, Mair FS, Haycox A, May CR, Williams TL, Hellmich S. Systematic review of cost effectiveness studies of telemedicine interventions. BMJ. 2002;324(7351):1434–7.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Holtz B, Lauckner C. Diabetes management via mobile phones: a systematic review. Telemed J E Health. 2012;18(3):175–84.CrossRefPubMedGoogle Scholar
  22. 22.
    Krishna S, Boren SA. Diabetes self-management care via cell phone: a systematic review. J Diabetes Sci Technol (Online). 2008;2(3):509–17.CrossRefGoogle Scholar
  23. 23.
    Nesari M, Zakerimoghadam M, Rajab A, Bassampour S, Faghihzadeh S. Effect of telephone follow-up on adherence to a diabetes therapeutic regimen. Jpn J Nurs Sci. 2010;7(2):121–8.CrossRefPubMedGoogle Scholar
  24. 24.
    Zolfaghari M, Mousavifar SA, Pedram S, Haghani H. The impact of nurse short message services and telephone follow-ups on diabetic adherence: which one is more effective? J Clin Nurs. 2012;21(13–14):1922–31.CrossRefPubMedGoogle Scholar
  25. 25.
    Wu L, Forbes A, Griffiths P, Milligan P, While A. Telephone follow-up to improve glycaemic control in patients with Type 2 diabetes: systematic review and meta-analysis of controlled trials. Diabet Med. 2010;27(11):1217–25.CrossRefPubMedGoogle Scholar
  26. 26.
    Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol. 2010;63(8):834–40.CrossRefPubMedGoogle Scholar
  27. 27.
    Saheb Sharif-Askari F, Saheb Sharif-Askari N, Javadi M, Gholami K. Adverse drug reactions reported to the drug and poison information center of Tehran. Iran. PLoS One. 2017;12(9):e0185450.CrossRefPubMedGoogle Scholar
  28. 28.
    Gholami K, Kamalinia G, Ahmadian Attari MM, Salamzadeh J. Three years evaluation of drug shortages from educational pharmacies in tehran. Iran J Pharm Res. 2012;11(2):565–72.PubMedPubMedCentralGoogle Scholar
  29. 29.
    Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens. 2008;10(5):348–54.CrossRefGoogle Scholar
  30. 30.
    Toobert DJ, Hampson SE, Glasgow RE. The summary of diabetes self-care activities measure: results from 7 studies and a revised scale. Diabetes Care. 2000;23(7):943–50.CrossRefPubMedGoogle Scholar
  31. 31.
    Wild D, Grove A, Martin M, Eremenco S, McElroy S, Verjee-Lorenz A, et al. Principles of good practice for the translation and cultural adaptation process for patient-reported outcomes (PRO) measures: report of the ispor task force for translation and cultural adaptation. Value Health. 2005;8(2):94–104.CrossRefPubMedGoogle Scholar
  32. 32.
    Suksomboon N, Poolsup N, Nge YL. Impact of phone call intervention on glycemic control in diabetes patients: a systematic review and meta-analysis of randomized, controlled trials. PLoS ONE. 2014;9(2):e89207.CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Krass I, Armour C, Mitchell B, Brillant M, Dienaar R, Hughes J, et al. The Pharmacy Diabetes Care Program: assessment of a community pharmacy diabetes service model in Australia. Diabet Med. 2007;24(6):677–83.CrossRefPubMedGoogle Scholar
  34. 34.
    Fera T, Bluml BM, Ellis WM. Diabetes ten city challenge: final economic and clinical results. J Am Pharm Assoc. 2009;49(3):383–91.CrossRefGoogle Scholar
  35. 35.
    American-Diabetes-Association. Standards of medical care in diabetes—2013. Diabetes Care. 2013;36(Suppl 1):S11–S66.Google Scholar
  36. 36.
    American-Diabetes-Association. 9. Cardiovascular disease and risk management. Diabetes Care. 2017;40(Supplement 1):S75–S87.Google Scholar
  37. 37.
    Asche C, LaFleur J, Conner C. A review of diabetes treatment adherence and the association with clinical and economic outcomes. Clin Ther. 2011;33(1):74–109.CrossRefPubMedGoogle Scholar
  38. 38.
    Tricco AC, Ivers NM, Grimshaw JM, Moher D, Turner L, Galipeau J, et al. Effectiveness of quality improvement strategies on the management of diabetes: a systematic review and meta-analysis. Lancet. 2012;379(9833):2252–61.CrossRefPubMedGoogle Scholar
  39. 39.
    Piette JD, Weinberger M, Kraemer FB, McPhee SJ. Impact of automated calls with nurse follow-up on diabetes treatment outcomes in a department of veterans affairs health care system. Diabetes Care. 2001;24(2):202–8.CrossRefPubMedGoogle Scholar
  40. 40.
    Miguel A, Hall A, Liu W, Garrett J, Ballew A, Yang TH, et al. Improving comprehensive medication review acceptance by using a standardized recruitment script: a randomized control trial. J Manag Care Spec Pharm. 2017;23(1):13–21.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Amir Sarayani
    • 1
    • 5
  • Mojgan Mashayekhi
    • 2
  • Marzieh Nosrati
    • 2
  • Zahra Jahangard-Rafsanjani
    • 3
  • Mohammadreza Javadi
    • 1
    • 3
  • Navid Saadat
    • 4
  • Sheyda Najafi
    • 2
  • Kheirollah Gholami
    • 1
    • 3
  1. 1.Research Center for Rational Use of DrugsTehran University of Medical SciencesTehranIran
  2. 2.Community Pharmacies, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  3. 3.Department of Clinical Pharmacy, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  4. 4.Endocrine Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran
  5. 5.Department of Pharmaceutical Outcomes and PolicyUniversity of FloridaGainesvilleUSA

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