International Journal of Clinical Pharmacy

, Volume 39, Issue 5, pp 1061–1069 | Cite as

Evaluation of effects of an operational multidisciplinary team on antibiotic use in the medium to long term at a French university hospital

  • Béatrice DemoréEmail author
  • Pauline Humbert
  • Emmanuelle Boschetti
  • Sibylle Bevilacqua
  • Isabelle Clerc-Urmès
  • Thierry May
  • Céline Pulcini
  • Nathalie Thilly
Research Article


Background Antibiotic-resistant bacteria are a major public health problem throughout the world. In 2006, in accordance with the national guidelines for antibiotic use, the CHRU of Nancy created an operational multidisciplinary antibiotic team at one of its sites. In 2011, a cluster-controlled trial showed that the operational multidisciplinary antibiotic team (the intervention) had a favourable short-term effect on antibiotic use and costs. Objective Our objective was to determine whether these effects continued over the medium to long term (that is, 2–7 years after creation of the operational multidisciplinary antibiotic team, 2009–2014). Setting The 1800-bed University Hospital of Nancy (France). Method The effect in the medium to long term is measured according to the same criteria and assessed by the same methods as the first study. A cluster controlled trial was performed on the period 2009–2014. The intervention group comprised 11 medical and surgical wards in settings where the operational multidisciplinary antibiotic team was implemented and the control group comprised 6 wards without this operational team. Main outcome measure Consumption of antibiotics overall and by therapeutic class (in defined daily doses per 1000 patient-days) and costs savings (in €). Results The reduction in antibiotic use and costs continued, but at a lower rate than in the short term (11% between 2009 and 2014 compared with 33% between 2007 and 2009) at the site of the intervention. The principal decreases concerned fluoroquinolones and glycopeptides. At the site without an operational multidisciplinary antibiotic team (the control group), total antibiotic use remained stable. Between 2009 and 2014, costs fell 10.5% in the intervention group and 5.7% in the control group. Conclusion This study shows that it is possible to maintain the effectiveness over time of such an intervention and demonstrates its role in defining a hospital’s antibiotic policy.


Antibiotics Antimicrobial stewardship intervention Consumption DDD France Intervention Multidisciplinary team 



We are grateful to Jo Ann Cahn for the translation and editing of the English version of this document.


This work was supported by University Hospitals of Nancy (Language translation and editing fees).

Conflicts of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Pharmacy, Brabois Hospital, University Hospital of NancyVandoeuvre-lès-NancyFrance
  2. 2.Faculté de PharmacieUMR 7565, SRSMC, CNRS – Lorraine UniversityNancy CedexFrance
  3. 3.Infectious Diseases DepartmentBrabois Hospital, University Hospital of NancyVandoeuvre-lès-NancyFrance
  4. 4.Unité ESPRI-BIOBASE, Plateforme d’Aide à la Recherche CliniqueBrabois Hospital, University Hospital of NancyVandoeuvre-lès-NancyFrance
  5. 5.Host-Environment Relation, EA 4369Lorraine UniversityNancyFrance
  6. 6.Plateforme d’Aide à la Recherche CliniqueBrabois Hospital, University Hospital of NancyVandoeuvre-lès-NancyFrance
  7. 7.EA 4360 ApemacLorraine UniversityNancyFrance

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