International Journal of Clinical Pharmacy

, Volume 38, Issue 2, pp 223–227 | Cite as

Consumption of medicinal plants by patients with heart diseases at a pharmacist-managed anticoagulation clinic in Brazil

  • Paula Mendonça Leite
  • Rachel Oliveira Castilho
  • Antonio Luiz Pinho Ribeiro
  • Maria Auxiliadora Parreiras MartinsEmail author
Short Research Report


Background Medicinal plants (MP) have been used for many years with the purpose of feeding and curing. Several MP may interfere in drug response and are not always considered as potential drug-interactors in clinical practice. Objective To investigate the consumption of MP by outpatients during a one-year follow-up. Method Patients with cardiopathy diagnosis and indication(s) for long-term use of warfarin were recruited at a pharmacist-managed anticoagulation clinic of a Brazilian public hospital. This research employed a descriptive method. The consumption of MP was examined regarding the type, frequency and forms of use. Results A total of 280 patients were studied. Most patients were female (54.6 %) with an average age of 56.8 ± 13.1 years. The consumption of MP was reported by 46 (16.4 %) patients, totalizing 59 occurrences. Lemon, lemon balm and plantain were the most common MP. The main pharmacological uses involved the digestive, urinary, and respiratory tracts. Tea was the predominant form of consumption (87 %). Twelve (33.3 %) plants presented potential herb-warfarin interactions according to the literature. Conclusion We described the consumption of MP among outpatients characterized by their complex disease status, propensity for adverse events, and socioeconomic limitations. These results may guide pharmacist interventions and procedures to prevent clinical complications.


Anticoagulants Heart diseases Medicinal plants Warfarin 



No special funding was received for this study.

Conflicts of interest

None of the authors had financial or personal relationships with other people or organizations that could inappropriately influence (bias) their work.


  1. 1.
    Tachjian A, Maria V, Jahangir A. Use of herbal products and potential interactions in patients with cardiovascular diseases. J Am Coll Cardiol. 2010;55(6):515–25.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Newman D, Cragg G. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012;75(3):311–35.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Li J, Vederas J. Drug discovery and natural products: End of an era or an endless frontier? Science. 2009;325(5937):161–5.CrossRefPubMedGoogle Scholar
  4. 4.
    Castilho RO, Bueno NR, Costa RB, Pott A, Pott VJ, Scheidt GN, Batista MS. Medicinal plants used by the Kaiowá and Guarani indigenous populations in the Caarapó Reserve, Mato Grosso do Sul, Brazil. Acta Botanica Brasílica. 2005;19(1):39–44.CrossRefGoogle Scholar
  5. 5.
    Mazzari A, Prieto J. Herbal medicines in Brazil: pharmacokinetic profile and potential herb-drug interactions. Front Pharmacol. 2014;5(162):1–12.Google Scholar
  6. 6.
    Martins MAP, Carlos PPS, Ribeiro DD, Nobre VA, César CC, Rocha MOC, Ribeiro ALP. Warfarin drug interactions: a comparative evaluation of the lists provided by five information sources. Eur J Clin Pharmacol. 2011;67(12):1301–8.CrossRefPubMedGoogle Scholar
  7. 7.
    Baker W, Cios D, Sander S, Coleman C. Meta-analysis to assess the quality of warfarin control in atrial fibrillation patients in the United States. J Manag Care Pharm. 2009;15(3):244–52.PubMedGoogle Scholar
  8. 8.
    Delgoda R, Younger N, Barrett C, Braithwaite J, Davis D. The prevalence of herbs use in conjunction with conventional medicines in Jamaica. Complement Ther Med. 2010;18(1):13–20.CrossRefPubMedGoogle Scholar
  9. 9.
    Ulbricht C, Chao W, Costa D, Rusie-Seamon E, Weissner W, Woods J. Clinical evidence of herb-drug interactions: a systematic review by the natural standard research collaboration. Curr Drug Metab. 2008;9(10):1063–120.CrossRefPubMedGoogle Scholar
  10. 10.
    Martins FS, Conceição EC. Evaluation of extraction method on the chemical composition in Apeiba tibourbou Aubl’s extracts. Pharmacogn Mag. 2015;11(42):368–73.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing 2016

Authors and Affiliations

  • Paula Mendonça Leite
    • 1
  • Rachel Oliveira Castilho
    • 1
  • Antonio Luiz Pinho Ribeiro
    • 1
  • Maria Auxiliadora Parreiras Martins
    • 1
    Email author
  1. 1.Universidade Federal de Minas GeraisBelo HorizonteBrazil

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