International Journal of Clinical Pharmacy

, Volume 36, Issue 1, pp 86–91 | Cite as

Non-adherence to antibiotic therapy in patients visiting community pharmacies

  • Milene FernandesEmail author
  • Andreia Leite
  • Maria Basto
  • Miguel Araújo Nobre
  • Nuno Vieira
  • Rui Fernandes
  • Paulo Nogueira
  • Paulo Jorge
Short Research Report


Background Patient non-adherence to antibiotic therapy may lead to therapeutic failure, re-infection, and bacterial resistance. Assessing the factors associated with this problem is important for promoting rational use of antibiotics. Objective This study aimed to measure prevalence and reasons for non-adherence to antibiotic treatment and to identify associated factors. Method Patients were recruited for the study in community pharmacies in Lisbon, Portugal, from February to April, 2009. Data from prescriptions for oral antibiotics were collected for adult subjects. Adherence to treatment was assessed with a modified Portuguese version of the Morisky scale. Factors associated with non-adherence were identified through bivariate analysis and logistic regression models. Results A total of 243 patients were included in the study. They had a mean age 46.5 ± 16.6 years and 74.5 % of the sample was female. The prevalence of non-adherence was 57.7 % and was related to delays and failures in taking the prescribed medicine. Increasing age (OR 0.97), difficulty in buying the antibiotic (OR 2.34), duration of treatment (OR 1.28), difficulty with ingestion (OR 3.08), and satisfaction with the information given by physician (OR 0.33) were identified as independent factors associated with non-adherence. Conclusion Non-adherence to antibiotics is common in the community setting. Factors related to the antibiotic, the patient, and the patient-physician relationship should be addressed to promote adherence. Pharmacists should provide information to patients about correct use of antibiotics and address barriers to adherence.


Antibiotics Bacterial resistance Community pharmacies Patient adherence Portugal 



Thanks are due to the participants and to the pharmacies that collaborated in the study, to the interviewers Inês Simões, Verónica Delgado and Maria Freitas, to Luís Caldeira and Fernando Fernandez-Llimos for additional comments on the article and to Yonah Yaphe for editorial assistance.


The study received a grant from the Merck, Sharp & Dohme Foundation (Portugal), with no influence on study design or data analysis.

Conflicts of interest

None to declare.


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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2013

Authors and Affiliations

  • Milene Fernandes
    • 1
    Email author
  • Andreia Leite
    • 1
  • Maria Basto
    • 1
    • 2
  • Miguel Araújo Nobre
    • 1
  • Nuno Vieira
    • 3
  • Rui Fernandes
    • 1
  • Paulo Nogueira
    • 1
    • 4
  • Paulo Jorge
    • 1
  1. 1.Faculty of Medicine, Institute of Preventive MedicineUniversity of LisbonLisbonPortugal
  2. 2.Medical DepartmentRottapharm|MadausLisbonPortugal
  3. 3.Internal Medicine DepartmentCentro Hospitalar do Barlavento AlgarvioPortimãoPortugal
  4. 4.General-Directorate of Health (DGS)LisbonPortugal

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