International Journal of Clinical Pharmacy

, Volume 35, Issue 5, pp 719–726 | Cite as

Implementation of medication reviews in community pharmacies and their effect on potentially inappropriate drug use in elderly patients

  • Martina TeichertEmail author
  • Susan Noyon Luijben
  • Anouk Wereldsma
  • Ton Schalk
  • Jacqueline Janssen
  • Michel Wensing
  • Peter de Smet
Research Article


Background In 2008 recommendations were launched to prevent medication-related hospital admissions in the Netherlands. Elderly patients using several drugs on a chronic basis were among the target group. Pharmacy-led medication reviews (MRs) were identified as having potential for improving patient safety. Objective This observational study evaluated the implementation success rate of performing all five steps of a complete MR for patients and changes in the presence of nine issues of potentially inappropriate medication (PIM) use. This change was compared between patients with a complete MR (intervention group, IG) and a reference group (RG) who attended the same pharmacy; all patients were eligible for MR, but only selected patients formed the IG. Setting Dutch community pharmacy. Method After appropriate training, the rate of IG with complete MRs was measured by pharmacists registering the various MR steps in the MR tool. Patients were eligible for a MR if aged ≥65 years with ≥5 drugs being used chronically. Main outcome measures The success rate of implementing MRs with five steps completed; the presence of nine PIMs for both study groups. Results In pharmacies with specifically trained pharmacists, 63 % of selected patients received a complete MR. This was 12 % higher than in pharmacies without trained pharmacists. PIMs reported at study start declined in the IG and at study end had decreased by an average of 19 % (with a range between 34 and 100 % per PIM); this decrease did not significantly differ from the RG. Conclusion Additional efforts are needed to improve the implementation of pharmacist-led MRs in order to realize its full potential in general practice, and for a substantial decrease of PIMs to occur in susceptible patients. These efforts should focus on training courses and additional support using computerized systems to share information with GPs and to register MR activities, together with sufficient financial reimbursement.


Drug safety Elderly Implementation Medication review Potentially inappropriate medication The Netherlands 



Achmea Health Care Insurance paid a fee to pharmacists who had attended the training course and completed MRs and registrations using the web-based tool for at least 20 eligible patients during the study period; 45 Euros per patient was paid per completed MR. Achmea was not involved in the design or conduct of the study, or the collection, management or analysis of data.

Conflicts of interest

We have no conflict of interest to report.

Supplementary material

11096_2013_9794_MOESM1_ESM.doc (46 kb)
Supplementary material 1 (DOC 46 kb)


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Martina Teichert
    • 1
    • 2
    Email author
  • Susan Noyon Luijben
    • 3
  • Anouk Wereldsma
    • 3
  • Ton Schalk
    • 2
    • 4
  • Jacqueline Janssen
    • 4
  • Michel Wensing
    • 1
  • Peter de Smet
    • 1
    • 2
  1. 1.Scientific Institute for Quality of Healthcare (IQ Healthcare)Radboud University Nijmegen Medical CentreNijmegenThe Netherlands
  2. 2.Koninklijk Nederlandse Maatschappij ter bevordering der PharmacieThe HagueThe Netherlands
  3. 3.AchmeaLeidenThe Netherlands
  4. 4.Stichting Farmaceutische KengetallenThe HagueThe Netherlands

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