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International Journal of Clinical Pharmacy

, Volume 35, Issue 3, pp 401–407 | Cite as

Characteristics of potential drug-related problems among oncology patients

  • Arjan BulsinkEmail author
  • Alex L. T. Imholz
  • Jacobus R. B. J. Brouwers
  • Frank G. A. Jansman
Research Article

Abstract

Background Oncology patients are more at risk for drug related problems because of treatment with (combinations of) anticancer drugs, as they have a higher risk for organ failure or altered metabolism with progression of their disease. Objective The aim of this study was to characterize and to evaluate the frequency of potential drug related problems (pDRPs) among oncology patients. Setting Outpatient- and day-care centres for Internal and Pulmonary Medicine at the Deventer Hospital, Deventer, The Netherlands. Method A prospective, descriptive, observational study was carried out from March 2010 to March 2011 at the Deventer Hospital, Deventer, The Netherlands. All patients older than 18 years receiving anticancer drugs prescribed by an internal medicineoncologist or pulmonologist-oncologist were included. Main outcome measure The primary outcome was the number and type of pDRPs according to Dutch guidelines. Results Among 546 patients with cancer, 952 pDRPs were identified, of which 474 were oncology-related. These were mainly drug interactions (IA) (246 IA in 157 patients) and potential contraindications (pCI) (201 pCI in 143 patients). Conclusion Most identified pDRPs in cancer patients were IAs and pCIs and involved corticosteroids. The most frequently occurring oncology-related IAs were classified as minor or moderate levels of severity.

Keywords

Contraindications Drug-drug interactions Drug-related problems Oncology The Netherlands 

Notes

Acknowledgments

The authors are grateful for the substantial contributions to this study of G.J. Altena, G.J. Borst, S.D. Boor and F. Karabulut, MSc students in pharmaceutical sciences, M.M. Voogel-Fuchs, staff member oncology, and of M.E.L. Arbouw, PharmD, PhD, Deventer Hospital, Deventer.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Conflicts of interest

No conflicts of interest to declare.

References

  1. 1.
    Association of Comprehensive Cancer Centers. Dutch cancer registration [database on the internet]. Amsterdam: Association of Comprehensive Cancer Centers [cited 2012 November 17]. Available from: www.iknl.nl.
  2. 2.
    Beijnen JH, Schellens JH. Drug interactions in oncology. Lancet Oncol. 2004;5:489–96.PubMedCrossRefGoogle Scholar
  3. 3.
    Riechelmann RP, Tannock IF, Wang L, Saad ED, Taback NA. Potential drug interactions and duplicate prescriptions among cancer patients. J Natl Cancer Inst. 2007;99:592–600.PubMedCrossRefGoogle Scholar
  4. 4.
    Voll ML, Yap KD, Terpstra WE, Crul M. Potential drug–drug interactions between anticancer agents and community pharmacy dispensed drugs. Pharm World Sci. 2010;32(5):575–80.PubMedCrossRefGoogle Scholar
  5. 5.
    Van Leeuwen RWF, Swart EL, Boven E, Boom FA, Schuitenmaker MG, Hugtenburg JG. Potential drug interactions in cancer therapy: a prevalence study using an advanced screening method. Ann Oncol. 2011;22(10):2334–41.PubMedCrossRefGoogle Scholar
  6. 6.
    Dutch Health Care Inspectorate. Circulaire 2005–6 cytostatica [report on the internet]. The Hague: Dutch Health Care Inspectorate; 2005 [cited 2012 November 17] Available from: www.igz.nl.
  7. 7.
    World Health Organization. International statistical classification of diseases and related health problems, 10th revision (ICD-10)—Dutch [database on the internet]. Geneva: World Health Organization; 2005-2011 [cited November 17]. Available from: http://class.who-fic.nl/browser.aspx.
  8. 8.
    Shumock GT, Thornton JP. Focussing on the preventability of adverse drug reactions. Hosp Pharm. 1992;27:538.Google Scholar
  9. 9.
    Van Den Bemt PMLA, Egberts ACG. Bijwerkingen en medicatiefouten systematisch ingedeeld. Pharm Weekbl. 2002;137:1540–3.Google Scholar
  10. 10.
    Jansman FGA, Reyners AKL, Van Roon EN, Smorenburg CH, Helgason HH, le Comte M, et al. Consensus-based evaluation of clinical significance and management of anticancer drug interactions. Clin Ther. 2011;33:305–14.PubMedCrossRefGoogle Scholar
  11. 11.
    Royal Dutch Association for the Advancement of Pharmacy. Dutch drug database [electronic database]. The Hague: Royal Dutch Association for the Advancement of Pharmacy [montly updates; cited November 17].Google Scholar
  12. 12.
    Van Roon EN, Flikweert S, le Comte M, Langendijk PN, Kwee-Zuiderwijk WJ, Smits P, et al. Clinical Relevance of drug–drug interactions: a structured assessment procedure. Drug Saf. 2005;28:1131–9.PubMedCrossRefGoogle Scholar
  13. 13.
    Facts and Comparisons. Drug Interaction Facts software [electronic database]. St. Louis: Wolters and Kluwer Health 2012.Google Scholar
  14. 14.
    Arizona Centre for Education and Research on Therapeutics. QT drug list [database on the internet] Tucson: Arizona Centre for Education and Research on Therapeutics [cited 2012 November 17]. Available from: www.azcert.org/medical-pros/drug-list/drug-lists.cfm.

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Arjan Bulsink
    • 1
    Email author
  • Alex L. T. Imholz
    • 2
  • Jacobus R. B. J. Brouwers
    • 3
    • 4
  • Frank G. A. Jansman
    • 1
    • 3
  1. 1.Department of Clinical Pharmacy (E3.019)Deventer HospitalDeventerThe Netherlands
  2. 2.Department of Internal MedicineDeventer HospitalDeventerThe Netherlands
  3. 3.Department of Pharmacotherapy and Pharmaceutical CareGroningen UniversityGroningenThe Netherlands
  4. 4.Department of GeriatricsUniversity Medical Centre Utrecht-EphorUtrechtThe Netherlands

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