International Journal of Clinical Pharmacy

, Volume 35, Issue 2, pp 251–259 | Cite as

Pediatric drug-related problems: a multicenter study in four French-speaking countries

  • Sonia Prot-Labarthe
  • Ermindo R. Di Paolo
  • Annie Lavoie
  • Stefanie Quennery
  • Jean-François Bussières
  • Françoise Brion
  • Olivier BourdonEmail author
Research Article


Background Pediatric intensive care patients represent a population at high risk for drug-related problems. There are few studies that compare the activity of clinical pharmacists between countries. Objective To describe the drug-related problems identified and interventions by four pharmacists in a pediatric cardiac and intensive care unit. Setting Four pediatric centers in France, Quebec, Switzerland and Belgium. Method This was a six-month multicenter, descriptive and prospective study conducted from August 1, 2009 to January 31, 2010. Drug-related problems and clinical interventions were compiled from four pediatric centers in France, Quebec, Switzerland and Belgium. Data on patients, drugs, intervention, documentation, approval and estimated impact were compiled. Main outcome measure Number and type of drug-related problems encountered in a large pediatric inpatient population. Results A total of 996 interventions were recorded: 238 (24 %) in France, 278 (28 %) in Quebec, 351 (35 %) in Switzerland and 129 (13 %) in Belgium. These interventions targeted 270 patients (median 21 months old, 53 % male): 88 (33 %) in France, 56 (21 %) in Quebec, 57 (21 %) in Switzerland and 69 (26 %) in Belgium. The main drug-related problems were inappropriate administration technique (29 %), untreated indication (25 %) and supra-therapeutic dose (11 %). The pharmacists’ interventions were mostly optimizing the mode of administration (22 %), dose adjustment (20 %) and therapeutic monitoring (16 %). The two major drug classes that led to interventions were anti-infectives for systemic use (23 %) and digestive system and metabolism drugs (22 %). Interventions mainly involved residents and all clinical staff (21 %). Among the 878 (88 %) proposed interventions requiring physician approval, 860 (98 %) were accepted. Conclusion This descriptive study illustrates drug-related problems and the ability of clinical pharmacists to identify and resolve them in pediatric intensive care units in four French-speaking countries.


Drug-related problems Pediatric intensive care unit Pharmaceutical care 



We thank the pediatric intensive care units and cardiology care teams at the various centers for their hospitality and availability, and Ariane Blanc for helping creating the database for data collection.


The program received a grant from Réseau Mère-Enfant de la Francophonie (RMEF, Francophone Mother Child Network).

Conflicts of interest



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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Sonia Prot-Labarthe
    • 1
  • Ermindo R. Di Paolo
    • 3
  • Annie Lavoie
    • 4
    • 6
  • Stefanie Quennery
    • 5
  • Jean-François Bussières
    • 4
    • 6
  • Françoise Brion
    • 1
    • 2
  • Olivier Bourdon
    • 1
    • 2
    Email author
  1. 1.Pharmacy Department, APHP, Hôpital Robert DebréParisFrance
  2. 2.Université Paris DescartesParisFrance
  3. 3.Pharmacy DepartmentCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  4. 4.Pharmacy DepartmentCHU Sainte JustineMontréalCanada
  5. 5.Pharmacy DepartmentCliniques Universitaires Saint-LucBrusselsBelgium
  6. 6.Faculty of PharmacyUniversité de MontréalMontrealCanada

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