International Journal of Clinical Pharmacy

, Volume 34, Issue 6, pp 828–831 | Cite as

Drug-related problems in patients with ischemic stroke in hospital

  • Carina HohmannEmail author
  • Tobias Neumann-Haefelin
  • Jürgen M. Klotz
  • Annette Freidank
  • Roland Radziwill
Short Research Report


Background Drug therapy is getting more complex, thus making it more challenging to prescribe appropriate drug therapy. Accordingly, in clinical practice, a wide range of drug-related problems (DRP) may arise; they are relatively common in hospitalised patients and can result in patient morbidity and mortality, and increased costs. Objective The objective was to investigate the nature and frequency of DRPs along with pharmaceutical interventions to address them in patients with ischemic stroke from hospital admission to discharge. Method From January to June 2011 patients with ischemic stroke, who were taking >2 drugs during hospital stay and at discharge, were recruited. A clinical pharmacist performed medication reconciliation on admission, and checked the medication records during the hospital stay regularly. DRPs were categorized by APS-Doc. Results In total, DRPs occurred in 105/155 (67.7 %) patients: Overall 271 DRPs were documented, with a mean of 1.8 ± 2.0 DRPs per patient. The DRPs occurred mainly in the categories “drug”, “indication”, and “dosage”. Conclusion In conclusion, DRPs are relatively common in hospitalised patients and may occur at any part of the prescribing process. The clinical pharmacist can provide a valuable contribution in the multidisciplinary team to an optimized pharmacotherapy in patients with ischemic stroke.


APS-Doc Drug-related problems Germany Hospital setting Ischemic stroke Pharmaceutical intervention 



Drug-related problem


Interquartile range


Modification of Diet in Renal Disease


Not available


Standard deviation


Transient ischemic attack



We would like to thank the participating patients and physicians who supported our study.



Conflicts of interest



  1. 1.
    van den Bemt PMLA, Egberts TCG, de Jong-van den Berg LTW, Brouwers JRBJ. Drug-related problems in hospitalised patients. Drug Saf. 2000;22(4):321–33.PubMedCrossRefGoogle Scholar
  2. 2.
    Kraehenbuehl-Melcher A, Schlienger R, Lampert M, Haschke M, Drewe J, Kraehenbuehl S. Drug-related problems in hospitals: a review of the recent literature. Drug Saf. 2007;30(5):379–407.CrossRefGoogle Scholar
  3. 3.
    The PCNE Classification V 6.02. Accessed 23 Jun 2012.
  4. 4.
    Michaels AD, Spinler SA, Leeper B, Ohman EM, Alexander KP, Newby LK, et al. Medication errors in acute cardiovascular and stroke patients: a scientific statement from the American Heart Association. Circulation. 2010;121(14):1664–82.PubMedCrossRefGoogle Scholar
  5. 5.
    Hohmann C, Eickhoff C, Klotz JM, Schulz M, Radziwill R. Development of a classification system for drug-related problems in the hospital setting (APS-Doc) and assessment of the inter-rater reliability. J Clin Pharm Ther. 2012;37(3):276–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Langebrake C, Hilgarth H. Clinical pharmacists’ interventions in a German university hospital. Pharm World Sci. 2010;32(2):194–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Hartel M, Staub L, Roder C, Eggli S. High incidence of medication documentation errors in a Swiss university hospital due to the handwritten prescription process. BMC Health Serv Res. 2011;11(1):199.PubMedCrossRefGoogle Scholar
  8. 8.
    Walker PC, Bernstein SJ, Tucker Jones JN, Piersma J, Kim HW, Regal RE, et al. Impact of a pharmacist-facilitated hospital discharge program. Arch Intern Med. 2009;169(21):2003–10.PubMedCrossRefGoogle Scholar
  9. 9.
    Blix HS, Vikttil KK, Moger TA, Reikvam A. Characteristics of drug-related problems discussed by hospital pharmacists in multidisciplinary teams. Pharm World Sci. 2006;28(3):152–8.PubMedCrossRefGoogle Scholar
  10. 10.
    Lampert ML, Kraehenbuehl S, Hug B. Drug-related problems: evaluation of a classification system in the daily practice of a Swiss University Hospital. Pharm World Sci. 2008;30(6):768–76.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Carina Hohmann
    • 1
    • 2
    Email author
  • Tobias Neumann-Haefelin
    • 2
  • Jürgen M. Klotz
    • 2
  • Annette Freidank
    • 1
  • Roland Radziwill
    • 1
  1. 1.Department of PharmacyKlinikum Fulda gAGFuldaGermany
  2. 2.Department of NeurologyKlinikum Fulda gAGFuldaGermany

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