International Journal of Clinical Pharmacy

, Volume 34, Issue 6, pp 818–821 | Cite as

Use of anticoagulation therapy for jugular vein thrombus in pediatric patients with Lemierre’s syndrome

  • Thuyvan Phan
  • Tsz-Yin SoEmail author
Case Report


Background Lemierre’s syndrome is a rare condition involving septic thrombophlebitis of the internal jugular vein secondary to an acute oropharyngeal infection. The low incidence and prevalence of Lemierre’s syndrome contribute to the many controversies pertaining to its therapeutic management, one of which is the use of anticoagulation for associated internal jugular vein thrombus. Case description A previously healthy 5-year-old male admitted with left internal jugular vein thrombosis associated with Lemierre’s syndrome was placed on appropriate antibiotics and anticoagulation therapy with enoxaparin. 3 weeks post-discharge, patient was found to be in good condition and a magnetic resonance angiography showed persistent occlusion of the left internal jugular vein. Conclusion Anticoagulation therapy for internal jugular vein thrombosis associated with Lemierre’s syndrome remains a controversy. In the absence of any contraindication or presumed risk, anticoagulation therapy should be considered in high risk patients.


Anticoagulation Jugular vein thrombus Lemierre’s syndrome Pediatrics 



No sources of funding were used to assist in the preparation of this article.

Conflicts of interest

The authors have no conflicts of interest that are directly related to the content of this article.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Department of PharmacyMoses H. Cone Memorial HospitalGreensboroUSA

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