Characteristics of HIV patients referred to a medication adherence program in Switzerland
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Background Since August 2004, HIV patients who encounter -or are at risk of -problems with their antiretroviral treatment (ART) are referred by their physician to a medication adherence program at the community pharmacy of the Department of Ambulatory Care and Community Medicine in Lausanne (Switzerland). The program combines motivational interviewing and electronic drug monitoring. Objective To compare the demographic and clinical characteristics as well as ART of HIV patients referred to the adherence program versus those of the entire HIV population followed in the same infection disease department in the same time frame. Method Retrospective descriptive cross-sectional study. Study time frame was defined according to the period with the highest number of HIV patients visiting the adherence program. Results Subjects included in the adherence program had more often a protease inhibitor-based regimen (64 %; 95 % CI [52–75 %] vs. 37 %) and lower CD4 cell counts (419 (252.0, 521.0); 95 % CI [305–472] vs. 500 (351.0, 720.0)) than the entire HIV population. A majority of women were included in the adherence program (66 %; 95 % CI [54–76 %] vs. 39% in the entire HIV population). Conclusion Subjects referred to the adherence program were different from the entire HIV population and showed worse clinical outcomes and were more often under salvage therapy. More women than men were included. Reasons for such a difference need to be further explored.
KeywordsAdherence program Antiretroviral therapy Cross-sectional studies HIV Intervention Medication adherence Pharmacists Switzerland
We acknowledge the members of the Swiss HIV Cohort Study for their support.
Conflicts of interest
Isabelle Krummenacher has no conflict of interest to declare. Matthias Cavassini received travel grants from Abbott and an unrestricted grant from Gilead. Olivier Bugnon received unrestricted grants from Abbott. Marie P. Schneider received a travel grant from Abbott and an unrestricted grant from Gilead.
- 1.American Public Health Association. Adherence to HIV treatment regimens: recommendations for best practices. [Internet]. 2004 June [cited 2011 May 18]. Available from: http://www.apha.org/NR/rdonlyres/A030DDB1-02C8-4D80-923B-7EF6608D62F1/0/BestPracticesnew.pdf.