Advertisement

International Journal of Clinical Pharmacy

, Volume 33, Issue 3, pp 471–472 | Cite as

Distinct mechanisms for rasburicase induced hemolytic anemia and methemoglobinemia in tumor lysis syndrome

  • Rodrigo Lopes da SilvaEmail author
Letter to the Editor

Keywords

Reactive Oxygen Species Uric Acid Acute Pancreatitis Xanthine Oxidase Hemolytic Anemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflicts of interest

None

References

  1. 1.
    Bauters T, Mondelaers V, Robays H, De Wilde H, Benoit Y, De Moerloose B. Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia. Int J Clin Pharm. 2011;33(1):58–60.PubMedCrossRefGoogle Scholar
  2. 2.
    Góth L. Rasburicase therapy may cause hydrogen peroxide shock. Orv Hetil. 2008;149(34):1587–90.PubMedCrossRefGoogle Scholar
  3. 3.
    Soares M, Feres GA, Salluh JI. Systemic inflammatory response syndrome and multiple organ dysfunction in patients with acute tumor lysis syndrome. Clinics (Sao Paulo). 2009;64(5):479–81.Google Scholar
  4. 4.
    Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA. 1981;78:6858–62.PubMedCrossRefGoogle Scholar
  5. 5.
    Góth L, Bigler NW. Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Free Radic Res. 2007;41(9):953–5.PubMedCrossRefGoogle Scholar
  6. 6.
    Browning LA, Kruse JA. Hemolysis and methemoglobinemia secondary to rasburicase administration. Ann Pharmacother. 2005;39(11):1932–5.PubMedCrossRefGoogle Scholar
  7. 7.
    Sweiry JH, Mann GE. Role of oxidative stress in the pathogenesis of acute pancreatitis. Scand J Gastroenterol Suppl. 1996;219:10–5.PubMedCrossRefGoogle Scholar
  8. 8.
    Folch E, Gelpí E, Roselló-Catafau J, Closa D. Free radicals generated by xanthine oxidase mediate pancreatitis-associated organ failure. Dig Dis Sci. 1998;43(11):2405–10.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Hospital Santo António dos Capuchos—CHLCLisbonPortugal

Personalised recommendations