Acute renal failure when exenatide is co-administered with diuretics and angiotensin II blockers
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Case (description) the patient is a 20 years old male smoker, who was diagnosed with type 2 diabetes mellitus in 2006. Due to the inadequate response to the previously established treatment, the pharmacotherapy was modified by introducing exenatide (up to 10 μg, twice daily) instead of insulin glargine, but maintaining the treatment with the diuretic and angiotensin II receptor antagonist drugs. Two months later, the patient exhibited a very important intolerance to exenatide (continuous nausea, vomiting, and dehydration), finally leading to ischemic acute renal failure. When the angiotensin II receptor antagonist and exenatide were suspended, a very rapid recovery of renal function was observed. Conclusion ischemic acute renal failure is supposed to be the consequence of the extracellular volume contraction caused by exenatide (the result of continuous nausea and vomiting). This adverse effect could be caused by the co-administration of diuretics and angiotensin II receptor antagonists.
KeywordsAdverse drug effect ADE Angiotensin II receptor antagonist Candesartan Combined therapy Diuretic Exenatide Hydrochlorothiazide Ischemic acute renal failure Renal function Type 2 diabetes mellitus
The cooperation of the Diabetes Unit of the Reina Sofía University Hospital (Murcia, Spain), of the Medical Department of Eli Lilly & Co. (Spain), and of Mr. Martin Urbanek are gratefully acknowledged.
No funding was received for this study.
Conflicts of interest
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