Pharmacy World & Science

, Volume 31, Issue 3, pp 365–368 | Cite as

Netilmicin in the neonate: pharmacokinetic analysis and influence of parenteral nutrition

  • Flora Bacopoulou
  • Maria Skouroliakou
  • Sophia L. MarkantonisEmail author
Short Research Report


Objective The aim of this study was to investigate the impact of parenteral nutrition on netilmicin pharmacokinetics in critically ill neonates during the first week of life. Method A total of 200 neonates (gestational ages 26.4–41 weeks) treated with netilmicin (4–5 mg/kg in extended dosing intervals) for postnatal sepsis in the first week of life received either fluid therapy or parenteral nutrition. Netilmicin peak and trough serum concentrations were monitored and netilmicin pharmacokinetic parameters were compared with and without parenteral nutrition. Results There were no statistically significant differences between the pharmacokinetic parameters of netilmicin (volume of distribution, elimination half-life, clearance) in critically ill neonates >32 weeks during the first week of life that received either fluid therapy or parenteral nutrition. For neonates <32 weeks this comparison was not feasible as the majority were parenterally fed. Conclusion Provision of parenteral nutrition (versus fluid therapy) in critically ill neonates >32 weeks did not significantly affect netilmicin pharmacokinetics and therefore does not require modification of recommended netilmicin dosage regimens.


Extended dosing intervals Neonates Netilmicin Parenteral nutrition Pharmacokinetics 



We thank Ms Amalia Papadopoulou, BPharm., MSc for her help in recording patient data.

Conflicts of interest

None declared.


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Flora Bacopoulou
    • 1
  • Maria Skouroliakou
    • 2
  • Sophia L. Markantonis
    • 1
    Email author
  1. 1.Faculty of Pharmacy, Laboratory of Biopharmaceutics and PharmacokineticsUniversity of AthensAthensGreece
  2. 2.Harokopio University, IASO Maternity HospitalAthensGreece

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