Two acute psychotic episodes after administration of bupropion: a case of involuntary rechallenge
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Bupropion is an antidepressant drug also used as a smoking cessation aid, which inhibits norepinephrine and dopamine re-uptake. Given its pharmacological properties, it has been associated with reports on psychosis and acute delirious episodes. Case We report the case of a patient with schizoaffective disorder who developed two psychotic episodes respectively after a four and a two-day administration of sustained-release (SR) bupropion at a dose of 150 mg/day. To our knowledge, this is the first reported case of involuntary rechallenge with bupropion SR during a smoking cessation program. Conclusion There is a serious risk of incorrectly identifying bupropion as only a therapy for nicotine withdrawal without taking the precaution of exploring possible psychiatric co-morbidity with addiction. Our case illustrates the problem.
KeywordsAcute psychosis Adverse drug reaction Bupropion Rechallenge Side effects
The authors want to express their gratitude to the translators, Mr Jean-Yves Bart and Mr Jesse David Tatum, for revising the text.
Conflicts of interest
All the authors of this article attest that there was no potential conflict of interest that could have influenced this work.