Pharmacy World & Science

, Volume 30, Issue 6, pp 753–758 | Cite as

Five-year follow-up of drug utilization for secondary prevention in coronary artery disease

  • Sule Apikoglu RabusEmail author
  • Fikret V. Izzettin
  • Mesut Sancar
  • Osman Karakaya
  • Ramazan Kargin
  • Cevat Yakut
Short Research Report


Objective Despite the availability of various prevention guidelines on coronary artery disease, secondary prevention practice utilizing aspirin, beta-blockers, angiotensin converting enzyme inhibitors and statins still can be sub-optimal. In this study, we aimed to assess the guideline adherence of secondary prevention prescribing and the continuity of adherence for a 5-year period in a small cohort of patients angiographically diagnosed to have coronary artery disease. Method In this prospective study, 73 patients who were angiographically diagnosed to have CAD were followed up for 5 years. The baseline demographic and clinical data were collected just before angiography. The baseline drug data were collected at the day of discharge. The fifth year data were taken from the patients via face-to-face consultations or phone interviews. Results The ‘initial prescribing rate’ at discharge was found to be 82% for aspirin, 49% for statins, 44% for ACE inhibitors and 55% for beta-blockers. ‘Continuity of prescribing’ for 5 years was 45% for aspirin, 26% for statins, 17% for ACE inhibitors and 20% for beta-blockers. Conclusions Besides the sub-optimal prescribing of secondary prevention drugs, absence of continuity of prescribing seems to be a challenging issue in pharmaceutical care of coronary artery disease patients.


Drug Utilisation Follow up Guideline Secondary prevention Coronary disease Turkey 



The study was carried out with no external funding.

Conflict of interest

The authors have no conflicts of interest.


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Sule Apikoglu Rabus
    • 1
    Email author
  • Fikret V. Izzettin
    • 1
  • Mesut Sancar
    • 1
  • Osman Karakaya
    • 2
  • Ramazan Kargin
    • 2
  • Cevat Yakut
    • 3
  1. 1.Clinical Pharmacy Department, Faculty of PharmacyMarmara UniversityIstanbulTurkey
  2. 2.Cardiology DepartmentKosuyolu Heart and Research HospitalIstanbulTurkey
  3. 3.Cardiovascular Surgery DepartmentKosuyolu Heart and Research HospitalIstanbulTurkey

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