Influencing the use of antibiotics in a Chinese pediatric intensive care unit
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Objectives To demonstrate the effectiveness of an intervention in antibiotics prescribing, and evaluate the use of antibiotics in the pediatric intensive care unit (PICU) at the Beijing Children’s Hospital. Methods Our interventions included (1) educating the pediatricians on antibiotics prescribing, (2) applying an antimicrobial spectrum chart, and (3) controlling the prescription of specific antibiotics with the use of a guideline. Nine hundred clinical records, including clinical information and antibiotic usage data, were selected retrospectatively from the PICU admissions during the pre- and post-intervention periods. Results In this 5-year survey, the mean rate of antibiotic prescribing was greater than 95% in the PICU. More than 76% of the prescriptions were started empirically. The most frequently used antibiotics were third-generation cephalosporins. After the intervention, we found a reduction in the rate of antibiotic cost/patient/day (P < 0.05); a decrease in the prescription rate of third-generation cephalosporins and macrolides (P < 0.01); an increase in the prescription rate of β-lactam/β-lactamase inhibitors and second-generation cephalosporins (P < 0.01); a reduction in the empiric treatment (P < 0.01); and a significant reduction in the incidence rates of bacterial resistance for imipenem-, cefepime-, and ceftazidime-resistant Pseudomonas aeruginosa (P < 0.05), and cefepime-resistant Escherichia coli and Klebsiella pneumoniae (P < 0.01). Conclusion Our interventions led to a significant reduction of broad-spectrum antibiotic prescribing associated with the significant reduction in bacterial resistance in the PICU. The implementation of the antibiotics guideline appeared to be effective.
KeywordsAntibiotic use China Intervention study Pediatric intensive care unit (PICU) Prescribing
This study was supported by a grant from the Ministry of Science and Technology of China (No. 2004BA720A09-01). We would like to thank all the participating pediatricians for their support.
MW was funded by a grant from Ministry of Science and Technology of China (No. 2004BA720A09-01).
Conflicts of interest
- 5.Bantar C, Sartori B, Vesco E, Heft C, Saul M, Salamone F, et al. A hospitalwide intervention program to optimize the quality of antibiotic use: impact on prescribing practice, antibiotic consumption, cost savings, and bacterial resistance. Clin Infect Dis. 2003;37(2):180–6.PubMedCrossRefGoogle Scholar
- 11.Zhou Hong LF. Analysis of usage of antibiotics and bacterial drug resistance in infected infants of pediatrics in Changchun (in Chinese). J Appl Clin Pediatr. 2006;21:1528–30.Google Scholar
- 13.Ministry of Public Health. Guidelines to use of antibiotics in clinic (in Chinese). Natl Med J China. 2004;84(23):2026–56.Google Scholar