Pharmacy World & Science

, Volume 30, Issue 4, pp 316–318 | Cite as

Interaction between methotrexate and omeprazole in an adolescent with leukemia: a case report

  • Tiene G. M. BautersEmail author
  • Joris Verlooy
  • Hugo Robays
  • Geneviéve Laureys
Case Report


We present a case of severe mucositis due to a drug–drug interaction between methotrexate (MTX) and omeprazole in an adolescent with Acute Lymphatic Leukemia (ALL). In view of the prevalence of MTX in many cytotoxic protocols, and the frequent use of omeprazole in the (ambulatory) oncology setting, we believe that this case-report is worth mentioning.


Drug-drug interaction Leukemia Methotrexate Omeprazole Pediatric oncology 


Conflicts of interest

There are no conflicts of interest nor funding.


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Tiene G. M. Bauters
    • 1
    Email author
  • Joris Verlooy
    • 2
  • Hugo Robays
    • 1
  • Geneviéve Laureys
    • 2
  1. 1.Department of PharmacyGhent University HospitalGhentBelgium
  2. 2.Department of Paediatric Hemato-OncologyGhent University HospitalGhentBelgium

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