Pharmacy World & Science

, Volume 30, Issue 4, pp 411–450 | Cite as

UKCPA Autumn 2006 Meeting


Lilly UK Critical Care Award 2006

Does computerised, decision-supported intensive insulin therapy achieve tighter glycaemic control than conventional insulin therapy?

R. Shulmana, N. Shahb, P. Glynnec, R. Greeneb

aDepartment of Pharmacy; cDepartment of Intensive Care, University College Hospital; bDepartment of Pharmacy, King’s University


Hyperglycaemia is associated with increased mortality in critical illness, and is related to excessive gluconeogenesis, relative insulin deficiency, and insulin resistance. Intensive insulin therapy (IIT), aiming for tight glycaemic control (TGC) [blood glucose (BG) 4.4–6.1 mmol/l], has resulted in a significant mortality and morbidity reduction compared to those treated with conventional treatment [1, 2]. The degree to which BG should be controlled is debated. Data from an observational study suggest that a less stringent target BG range of 4–8 mmol/l may achieve similar mortality benefits [3]. Complex protocols are required to achieve...

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© Springer Science+Business Media B.V. 2008

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