Pharmacy World & Science

, Volume 29, Issue 4, pp 404–411 | Cite as

The burden-of-illness study on osteoporosis in the Slovenian female population

  • Biljana DzajkovskaEmail author
  • Albert I. Wertheimer
  • Ales Mrhar
Original Paper


Study objective

This burden-of-illness study on osteoporosis was performed with the main goal to estimate the economic implications of osteoporosis for the Slovenian healthcare system.


A variety of sources was used to quantify the utilization of resources in 2003, and the appropriate unit costs were assigned to the identified resources.

Main outcome measures

The study included all direct and indirect costs that arise from treatment of osteoporosis and consequent hip, spine and wrist fractures in total Slovene postmenopausal population in 2003.


We estimated the total burden of postmenopausal osteoporosis in Slovenia for 2003 to be over SIT 7.55 billion (approximately €31.5 million); among that, 45% or SIT 3.39 billion (€14.2 million) belong to drug expenditures for osteoporosis treatment and prevention; 29% or SIT 2.2 billion (€9.2 million) include indirect costs for osteoporosis morbidity and mortality, and 26% or SIT 1.95 billion (€8.1 million) belong to direct costs for treatment, hospitalization, and rehabilitation of osteoporotic fractures. Total costs on osteoporotic fractures were however subject to an approximation due to the expert panel-based estimate of proportion of osteoporosis-caused fractures and the limited data on resource utilization for fracture treatment.


Osteoporosis is a costly disease with a significant burden to society and needs to be viewed as an important problem with a complex long-term impact.


Bone fractures  Burden-of-illness  Costs Economics Health policy  Osteoporosis Slovenia 



Biljana Dzajkovska wishes to thank the Slovenian Scientific Foundation for the given fellowship during the postgraduate studies. No sources of funding were used in the preparation of this paper.

Conflicts of Interest

The authors have no conflicts of interest that are directly relevant to the contents of this manuscript.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Biljana Dzajkovska
    • 1
    • 2
    Email author
  • Albert I. Wertheimer
    • 3
  • Ales Mrhar
    • 2
  1. 1.Millennium Pharmaceuticals, Ltd.LondonUK
  2. 2.Department of Biopharmaceutics and PharmacokineticsFaculty of PharmacyLjubljanaSlovenia
  3. 3.Center for Pharmaceutical Health Services ResearchTemple University School of PharmacyPhiladelphiaUSA

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