Pharmacy World & Science

, Volume 29, Issue 5, pp 565–572 | Cite as

Impact of a multidisciplinary approach on antibiotic consumption, cost and microbial resistance in a Czech hospital

  • Rene Mach
  • Jiri VlcekEmail author
  • Miroslava Prusova
  • Petr Batka
  • Vladan Rysavy
  • Ales Kubena
Original Paper



The study objective was to evaluate the impact of a restrictive antibiotic policy, efficacy of inpatient therapeutic and prophylactic antibiotic regimens and susceptibility patterns of infecting bacteria in 2000–2004.


A 500-bed general hospital in the Czech Republic.


A retrospective computerized survey of antibiotic prescribing practices over a five-year period 2000–2004, using medical records and laboratory data from the hospital information system (HIS).

Main outcome measure

Consumption of antibiotics expressed in defined daily doses (DDDs) and Euros per 1,000 bed days. Resistance to antibiotics, average length of hospital stay, rate of inpatients treated with antibiotics, number of nosocomial infections per 1,000 bed days, median length of hospital stay and total mortality.


Due to a restrictive antibiotic policy implemented in 2002, the use of several antibiotics in 2003 was significantly reduced but the consumption of several other antibiotics rose in 2003. In comparison with 2001 the cost of antibiotic agents (in € per 1,000 inpatient days) fell significantly by 31% in 2003 (€ 969.07 vs. € 671.34). The hospital saved about € 29,288 after the first year of implementation of the new antibiotic policy. The use of restricted antibiotics increased by 8%; however, the expenditure decreased by 26%. For non-restricted antibiotics, the use and expenditure decreased by 71% and 41%, respectively. Consequently, a net reduction of 55% (€ 804.36 vs. € 359.36) was achieved.


The intervention was effective in reducing the use and cost of antibiotics. The HIS is a helpful tool for observing and evaluating the impacts of the measures taken and can be used for assessment of pharmacotherapy outcomes.


Antibiotics Antibiotic policy Hospital information system Czech Republic 



We like to thank all of the health-care professionals who participated in this study. The study was funded by the Breclav Hospital.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Rene Mach
    • 1
  • Jiri Vlcek
    • 2
    Email author
  • Miroslava Prusova
    • 3
  • Petr Batka
    • 4
  • Vladan Rysavy
    • 5
  • Ales Kubena
    • 2
  1. 1.Department of PharmacyBreclav HospitalBreclavCzech Republic
  2. 2.Department of Social and Clinical Pharmacy, Faculty of PharmacyCharles UniversityHradec KraloveCzech Republic
  3. 3.Department of MicrobiologyBreclav HospitalBreclavCzech Republic
  4. 4.Department of InformaticsBreclav HospitalBreclavCzech Republic
  5. 5.Department of Internal MedicineBreclav HospitalBreclavCzech Republic

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