Pharmacy World and Science

, Volume 28, Issue 5, pp 326–328 | Cite as

Extreme thrombocytosis under the treatment by amoxicillin/clavulanate

  • Chih-Jen Yang
  • Jhi-Jhu Hwang
  • Jen-Yu Hung
  • Inn-Wen Chong
  • Ming-Shyan HuangEmail author
Case Report


Amoxicillin/Clavulanate related extreme thrombocytosis during the treatment of pneumonia has never been reported. We present a 54-year-old patient who was admitted due to pneumonia, and was treated with amoxicillin/clavulanate IV and 3-day course of 500 mg azithromycin. Despite clinical and radiological evidence showing that pneumonia improved, thrombocytes increased rapidly. After stopping the antibiotic, the thrombocytes returned gradually to normal. Considering the clinical course, we propose that this extreme thrombocytosis was caused by the administration of amoxicillin/clavulanate. We describe this rare and unique patient and review the literature.


Thrombocytosis Amoxicillin/clavulanate Adverse events 


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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Chih-Jen Yang
    • 1
  • Jhi-Jhu Hwang
    • 1
  • Jen-Yu Hung
    • 1
  • Inn-Wen Chong
    • 1
  • Ming-Shyan Huang
    • 1
    Email author
  1. 1.Division of Pulmonary and Critical Care Medicine, Department of Internal MedicineKaohsiung Medical University HospitalKaohsiungTaiwan

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