Pharmacy World and Science

, Volume 28, Issue 2, pp 96–100 | Cite as

Variations in Small-Volume Doses of a Liquid Antibiotic Using Two Paediatric Administration Devices

  • Therése E. KairuzEmail author
  • Patrick A. Ball
  • Ralph E. K. Pinnock
short research report



Children can be a difficult population in which to administer medicines and many parents or caregivers may be inexperienced in the administration of paediatric medicines. The aim of this study was to determine the variations in volumes of doses of reconstituted antibiotic suspension using two calibrated administrative devices.


Measurements were conducted in a Dispensing Laboratory in New Zealand, using locally available commercial, standardized measuring devices.


A medicine dropper and a spill-proof measuring spoon were selected and a dose of 3 ml, to be given three times daily for five days (45 ml) was used for the purposes of this study. Doses were weighed and corresponding volumes were calculated using the average weight per ml.


The doses measured using the medicine dropper were consistently smaller than the doses measured using the spill-proof measuring spoon.


The current method of financial subsidy for the provision of liquid antibiotics in New Zealand should be investigated. Pharmacists must ensure that an appropriate measure and sufficient quantity is provided for optimal duration of treatment. This study contributes to the relatively sparse information available on the administration of children’s medicines. It will have relevance for countries where pharmacy practice is determined largely by administrative departments.


Antibiotics Children Dose Volume Liquid Medicines Peadiatric Dosing 


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Maree Jensen, for advice on New Zealand pharmacy practice.

The School of Pharmacy, University of Auckland, for resources for this study.


  1. 1.
    Nunn T. Proceedings of the 64th international congress of the International Pharmaceutical Federation (FIP), in association with the American Pharmacists Association, the American Society of Health-System Pharmacists and the American Association of Pharmaceutical Scientists, New Orleans, Lousiana, Sept 4–9. Pharm J 2004; 23(Sept 25):434–6.Google Scholar
  2. 2.
    Lambers S. Encouraging adherence in children with HIV infection. Pharm J 261(Nov 28):862–3.Google Scholar
  3. 3.
    Mattar ME, Markello J, Yaffe SJ. Pharmaceutic factors affecting pediatric compliance. Pediatric 1975; 55(1):101–8.Google Scholar
  4. 4.
    Holliman R. Proceedings of the 59th international congress of the International Pharmaceutical Federation (FIP), Barcelona, Spain, Sept 5–10. Pharm J 1999; 263(Oct 9):609.Google Scholar
  5. 5.
    Ministry of Health, New Zealand. PHARMAC (Pharmaceutical Management Agency) Annual Review 2004. (30 August 2005).
  6. 6.
    New Zealand Pharmaceutical Schedule. Wellington: Pharmaceutical Management Agency; August 2004.Google Scholar
  7. 7.
    Kemp CA, McDowell JM, editors. Paediatric pharmacopoeia. 13th ed. Pharmacy Department, Royal Children’s Hospital, Australia; 2002.Google Scholar
  8. 8.
    Monk PM, Ball PA. The accuracy of a paediatric dosing device. Aus J Hospital Pharm 1997; 27:323–4.Google Scholar
  9. 9.
    Conroy S, Collier J, Birchley N, Niel K, Rodgers S, McIntyre J, et al. An examination of the risk management issues in the handling at home of over-the-counter medicines purchased for children. Pharm J 2003; 271(7262):209–13.Google Scholar
  10. 10.
    Bellingham C. Starting out right: the Children’s NSF. Pharm J 2003; 270(7245):539–40Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Therése E. Kairuz
    • 1
    Email author
  • Patrick A. Ball
    • 2
  • Ralph E. K. Pinnock
    • 3
  1. 1.School of Pharmacy, Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand
  2. 2.Charles Sturt UniversityWagga WaggaAustralia
  3. 3.Starship Children’s HospitalUniversity of AucklandAucklandNew Zealand

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