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Pharmaceutical Research

, 37:32 | Cite as

Correction to: Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Nonobese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study

  • Cornelis Smit
  • Roeland E. Wasmann
  • Marinus J. Wiezer
  • Hendricus P. A. van Dongen
  • Johan W. Mouton
  • Roger J. M. Brüggemann
  • Catherijne A. J. KnibbeEmail author
Correction
  • 341 Downloads

Correction to: Pharm Res (2019) 36: 112

  https://doi.org/10.1007/s11095-019-2651-2

There was a mistake in the units of CL and Q, and in the parentheses of the formula for CL in the final model in Table 2. The corrected Table appears below.
Table 2

Population pharmacokinetic parameters of the base and final tobramycin model and results of the bootstrap analysis

 

Base model (%RSE)

Final model (%RSE)

Bootstrap final model (n = 1000)

    

(95% Confidence interval)

     

Mean

Lower

Upper

Vc (L)

17.2

(7.3)

    

Vc = Vc70kg * (TBW/70)

       

Vc 70 kg (L)

 

10.6

(11)

10.6

8.94

12.4

CL (L/h)

6.42

(4.3)

    

CL = CLMDRD 115 * (1 + Z * (MDRD-115))

       

CLMDRD 115 (L/h)

 

6.33

(2.6)

6.33

6.02

6.63

Z

 

0.00990

(10)

0.0100

0.0880

0.0122

Vp (L)

4.24

(15)

4.34

(18)

4.41

2.84

5.98

Q (L/h)

6.4

(5.1)

6.69

(12)

6.77

2.63

10.91

Inter-individual variability (IIV, %)

     

Vc

42.9

(9.3)

24.9a

(17)

24.1

14.9

30.8

CL

25.2

(14)

12.0a

(13)

11.7

7.90

14.5

Residual variability

       

Proportional error

0.112

(12)

0.116

(12)

0.115

0.0880

0.141

Additive error (mg/L)

0.369

(13)

0.346

(12)

0.342

0.239

0.445

OFV

351.7

 

289.6

 

276.6

185.9

367.2

aη-shrinkage in the final model is 8% for IIV on CL and 6% for IIV on Vc. CL Clearance from the central compartment, CLMDRD 115 Clearance from the central compartment for a person with a MDRD of 115 ml/min, MDRD De-indexed Modification of Diet in Renal Disease (in ml/min), OFV Objective Function Value, Q intercompartmental clearance between VC and VP, RSE Relative standard error, TBW Total body weight in kg, Vc Central volume of distribution, Vc70 kg Central volume of distribution for a 70 kg person

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Cornelis Smit
    • 1
    • 2
  • Roeland E. Wasmann
    • 3
  • Marinus J. Wiezer
    • 4
  • Hendricus P. A. van Dongen
    • 5
  • Johan W. Mouton
    • 6
  • Roger J. M. Brüggemann
    • 3
  • Catherijne A. J. Knibbe
    • 1
    • 2
    Email author
  1. 1.Department of Clinical PharmacySt. Antonius HospitalNieuwegeinThe Netherlands
  2. 2.Department of Systems Biomedicine and PharmacologyLeiden Academic Centre for Drug Research Leiden UniversityLeidenThe Netherlands
  3. 3.Department of PharmacyRadboud Institute for Health SciencesNijmegenThe Netherlands
  4. 4.Department of SurgerySt. Antonius HospitalNieuwegeinThe Netherlands
  5. 5.Department of AnesthesiologySt. Antonius HospitalNieuwegeinThe Netherlands
  6. 6.Department of Medical Microbiology and Infectious DiseasesRotterdamThe Netherlands

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