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Pharmaceutical Research

, Volume 34, Issue 5, pp 941–956 | Cite as

The Properties of HPMC:PEO Extended Release Hydrophilic Matrices and their Response to Ionic Environments

  • Anran Hu
  • Chen Chen
  • Michael D. MantleEmail author
  • Bettina Wolf
  • Lynn F. Gladden
  • Ali Rajabi-Siahboomi
  • Shahrzad Missaghi
  • Laura Mason
  • Colin D. Melia
Research Paper

Abstract

Purpose

Investigate the extended release behaviour of compacts containing mixtures of hydrophilic HPMC and PEO in hydrating media of differing ionic strengths.

Methods

The extended release behaviour of various HPMC:PEO compacts was investigated using dissolution testing, confocal microscopy and magnetic resonance imaging, with respect to polymer ratio and ionic strength of the hydrating media.

Results

Increasing HPMC content gave longer extended release times, but a greater sensitivity to high ionic dissolution environments. Increasing PEO content reduced this sensitivity. The addition of PEO to a predominantly HPMC matrix reduced release rate sensitivity to high ionic environments. Confocal microscopy of early gel layer development showed the two polymers appeared to contribute independently to gel layer structure whilst together forming a coherent and effective diffusion barrier. There was some evidence that poorly swollen HPMC particles added a tortuosity barrier to the gel layer in high ionic strength environments, resulting in prolonged extended release. MRI provides unique, non-invasive spatially resolved information from within the HPMC:PEO compacts that furthers our understanding of USP 1 and USP 4 dissolution data.

Conclusions

Confocal microscopy and MRI data show that combinations of HPMC and PEO have advantageous extended release properties, in comparison with matrices containing a single polymer.

KEY WORDS

confocal fluorescence microscopy digital imaging dissolution HPMC hydrophilic matrix MRI PEO polymer mixtures 

ABBREVIATIONS

HPMC

Hydroxypropyl methylcellulose

MRI

Magnetic resonance imaging

PEO

Polyethylene oxide

Notes

ACKNOWLEDGMENTS AND DISCLOSURES

Yewande Oni from University of Nottingham.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Anran Hu
    • 1
  • Chen Chen
    • 2
  • Michael D. Mantle
    • 2
    Email author
  • Bettina Wolf
    • 3
  • Lynn F. Gladden
    • 2
  • Ali Rajabi-Siahboomi
    • 4
  • Shahrzad Missaghi
    • 4
  • Laura Mason
    • 1
  • Colin D. Melia
    • 1
  1. 1.Formulation InsightsSchool of PharmacyNottinghamUK
  2. 2.Department of Chemical Engineering and BiotechnologyUniversity of CambridgeCambridgeUK
  3. 3.Food Sciences, School of BiosciencesUniversity of NottinghamLoughboroughUK
  4. 4.Colorcon Inc., Global HeadquartersHarleysvilleUSA

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