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Pharmaceutical Research

, Volume 32, Issue 6, pp 2086–2096 | Cite as

Multi-Scale Modelling of Powder Dispersion in a Carrier-Based Inhalation System

  • Zhenbo Tong
  • Hidehiro Kamiya
  • Aibing Yu
  • Hak-Kim Chan
  • Runyu YangEmail author
Research Paper

ABSTRACT

Purpose

Carrier-based dry powder inhalers (DPIs) are widely used for rapid and convenient delivery of drug to the site of action. This work aimed to predict powder aerosolisation in DPIs through numerical modelling.

Methods

A multi-scale modelling technique based on the combined computational fluid dynamics (CFD) and discrete element method (DEM) approach was developed.

Results

The simulation results of the detachments of the drug particles from single carrier under different impact velocities and angles were comparable with those measured in the experiments in terms of fine particle fraction FPF loaded . Empirical equations were developed to link the detachment performance with impact velocity and impact angle. Then the dynamics of the carrier particles in Aerolizer® was simulated. The results indicated that the carrier-wall impaction was the dominant mechanism for drug aerosolisation performance. By linking the empirical equations with the carrier-wall impact energy, the predictions showed that for a given formulation mass with a fixed carrier/drug ratio, the inhaler performance decreased with carrier size and increased with air flow rate. Device empty efficiency, however, was independent with carrier size and flow rate.

Conclusions

The multi-scale model was able to provide quantitative information to better understand the aerosolisation mechanisms of carrier-based formulation.

KEY WORDS

carrier-based formulation computational fluid dynamics discrete element method dry powder inhaler numerical modelling powder dispersion 

Notes

ACKNOWLEDGMENTS AND DISCLOSURES

Authors are grateful to the Japan Society for the Promotion of Science (JSPS) and the Australia Research Council (ARC) for the financial support through the Discovery Project.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Zhenbo Tong
    • 1
    • 2
  • Hidehiro Kamiya
    • 1
  • Aibing Yu
    • 2
    • 3
  • Hak-Kim Chan
    • 4
  • Runyu Yang
    • 2
    Email author
  1. 1.Graduate School of Bio-Applications and Systems Engineering (BASE)Tokyo University of Agriculture and TechnologyTokyoJapan
  2. 2.School of Materials Science and EngineeringUniversity of New South WalesSydneyAustralia
  3. 3.Department of Chemical EngineeringMonash UniversityClaytonAustralia
  4. 4.Faculty of PharmacyUniversity of SydneySydneyAustralia

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