Pharmaceutical Research

, Volume 31, Issue 10, pp 2563–2582 | Cite as

Biomaterials for Nanoparticle Vaccine Delivery Systems

Expert Review

Abstract

Subunit vaccination benefits from improved safety over attenuated or inactivated vaccines, but their limited capability to elicit long-lasting, concerted cellular and humoral immune responses is a major challenge. Recent studies have demonstrated that antigen delivery via nanoparticle formulations can significantly improve immunogenicity of vaccines due to either intrinsic immunostimulatory properties of the materials or by co-entrapment of molecular adjuvants such as Toll-like receptor agonists. These studies have collectively shown that nanoparticles designed to mimic biophysical and biochemical cues of pathogens offer new exciting opportunities to enhance activation of innate immunity and elicit potent cellular and humoral immune responses with minimal cytotoxicity. In this review, we present key research advances that were made within the last 5 years in the field of nanoparticle vaccine delivery systems. In particular, we focus on the impact of biomaterials composition, size, and surface charge of nanoparticles on modulation of particle biodistribution, delivery of antigens and immunostimulatory molecules, trafficking and targeting of antigen presenting cells, and overall immune responses in systemic and mucosal tissues. This review describes recent progresses in the design of nanoparticle vaccine delivery carriers, including liposomes, lipid-based particles, micelles and nanostructures composed of natural or synthetic polymers, and lipid-polymer hybrid nanoparticles.

KEY WORDS

Nanoparticle Vaccination Subunit vaccine Liposomes Polymeric particles 

ABBREVIATIONS

aAPC

Artificial antigen presenting cell

APC

Antigen-presenting cell

BSA

Bovine serum albumin

CFA

Complete Freund’s adjuvant

CpG

Oligonucleotide with unmethylated CpG motifs

cSLN

Cationic solid lipid nanoparticles

CTL

Cytotoxic T-cell lymphocyte

DC

Dendritic cell

DC-Chol

3β-[N-(N’,N’-Dimethylaminoethane)-carbamoyl] cholesterol

DDA

Dimethyl dioctadecyl-ammonium

dLNs

Draining lymph nodes

DOPE

Dioleoyl phosphatidyl ethanolamine

DOTAP

1,2-dioleoyl-3-trimethylammoninum propane

DPPC

1,2-Dipalmitoyl-sn-glycero-3-phosphocholine

DPTAP

1,2-Dipalmitoyl-3-trimethylammonium-propane

dsRNA

Double stranded RNA

eDPPC

1,2-Diacyl-sn-glycero-3-ethylphosphocholine

HA

Hyaluronic acid

HIV

Human immunodeficiency virus

Hla

Staphylococcal α-haemolysin

HPV

Human papillomavirus

ICMVs

Interbilayer-crosslinked multilamellar vesicles

LPNs

Lipid-polymer hybrid nanoparticles

MHC-I

Major histocompatibility complex class I

MHC-II

Major histocompatibility complex class I

MPLA

Monophosphoryl lipid A

NK

Natural killer

NKT

Natural killer T-cell

NLR

Nod-like receptor

OVA

Ovalbumin

PAMP

Pathogen associated molecular pattern

PBAE

Poly-(β-amino ester)

PCL

Poly(ε-caprolactone)

PEG

Poly(ethylene glycol)

PEI

Polyethyleneimine

PGA

Poly(glycolic acid)

PHB

Poly(hydroxybutyrate)

PLA

Poly(lactic acid)

PLGA

Poly(lactic-co-glycolic acid)

PMMA

Polymethylmethacrylate

polyI:C

Polyinosinic:cytidylic acid

PPAA

Poly(propylacrylic acid)

PPS

Polypropylene sulfide

PRR

Pattern-recognition receptor

R8

Octaarganine

SIV

Simian immunodeficiency virus

TB

Mycobacterium tuberculosis

TDB

Trehalose dibehenate

Th1

T helper type 1

Th2

T helper type 2

TLR

Toll-like receptor

TMC

Trimethyl chitosan

α-galcer/αGC

Alpha-galactosyl ceramide

γ-PGA

Gamma polyglutamic acid

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Preety Sahdev
    • 1
    • 2
  • Lukasz J. Ochyl
    • 1
    • 2
  • James J. Moon
    • 1
    • 2
    • 3
  1. 1.Department of Pharmaceutical SciencesCollege of Pharmacy University of MichiganAnn ArborUSA
  2. 2.Biointerfaces InstituteUniversity of MichiganAnn ArborUSA
  3. 3.Department of Biomedical EngineeringCollege of Engineering University of MichiganAnn ArborUSA

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