Pharmaceutical Research

, Volume 30, Issue 1, pp 81–89 | Cite as

Solid-Solid Transformation in Racemic Ibuprofen

  • Emeline Dudognon
  • Natália T. Correia
  • Florence Danède
  • Marc Descamps
Research Paper

Abstract

Purpose

To clarify the polymorphism of racemic Ibuprofen and to determine the kinetic of the phase transformation that follows crystallisation of phase II.

Methods

Differential Scanning Calorimetry (DSC), X-ray powder diffraction and Hot Stage Microscopy are complementarily used to perform a kinetic investigation of the particular temperature range where competition between the occurrence of phases I and II is suspected.

Results

Experiments performed with the three techniques reveal that at 273 K the crystallisation to phase II is then followed by a solid-solid transition towards phase I. This transformation is exothermic (conversion enthalpy of 8.0 ± 0.5 kJ/mol), which proves that the two phases form a monotropic set. The kinetics of conversion deduced from X-Ray experiments follows a Johnson-Mehl-Avrami equation and the Hot Stage Microscopy allows us to establish that the transformation proceeds by the growth of some nuclei of phase I probably formed at lower temperature.

Conclusions

These results allow us to precise the stability pattern of racemic Ibuprofen and to establish the kinetic conditions of appearance and interconversion of the different phases. Therefore such real time resolved investigations would help if applied in the screening of polymorphs when competitive crystallisations occur.

KEY WORDS

ibuprofen monotropic solid-solid transition 

Notes

Acknowledgments and Disclosures

Financial support to Fundação para a Ciência e Tecnologia (FCT, Portugal) through the project PTDC/CTM/098979/2008 is acknowledged. This work was also supported by the interreg IV “2 mers seas zeeën” cross-border cooperation programme 2007–2013.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Emeline Dudognon
    • 1
  • Natália T. Correia
    • 1
    • 2
  • Florence Danède
    • 1
  • Marc Descamps
    • 1
  1. 1.Unité Matériaux Et Transformations, UMR CNRS 8207Université Lille Nord de FranceVilleneuve d’Ascq CedexFrance
  2. 2.REQUIMTE, Departamento de Química Faculdade de Ciências e TecnologiaUniversidade Nova de LisboaCaparicaPortugal

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