Pharmaceutical Research

, Volume 28, Issue 7, pp 1480–1499 | Cite as

Protein Microarrays: Novel Developments and Applications

  • Luis Berrade
  • Angie E. Garcia
  • Julio A. Camarero
Expert Review

ABSTRACT

Protein microarray technology possesses some of the greatest potential for providing direct information on protein function and potential drug targets. For example, functional protein microarrays are ideal tools suited for the mapping of biological pathways. They can be used to study most major types of interactions and enzymatic activities that take place in biochemical pathways and have been used for the analysis of simultaneous multiple biomolecular interactions involving protein-protein, protein-lipid, protein-DNA and protein-small molecule interactions. Because of this unique ability to analyze many kinds of molecular interactions en masse, the requirement of very small sample amount and the potential to be miniaturized and automated, protein microarrays are extremely well suited for protein profiling, drug discovery, drug target identification and clinical prognosis and diagnosis. The aim of this review is to summarize the most recent developments in the production, applications and analysis of protein microarrays.

KEY WORDS

drug discovery protein chips protein immobilization protein profiling proteomics 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Luis Berrade
    • 1
  • Angie E. Garcia
    • 1
  • Julio A. Camarero
    • 1
  1. 1.Department of Pharmacology and Pharmaceutical Sciences School of PharmacyUniversity of Southern CaliforniaLos AngelesUSA

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