Pharmaceutical Research

, Volume 27, Issue 12, pp 2776–2780 | Cite as

Quantitative Aspects of Intracellularly-Targeted Drug Delivery

  • David StepenskyEmail author


Many pharmacological agents act intracellularly, need to be endocytosed, and reach the site of action in specific organelle to exert their action. The cell’s interior is highly compartmentalized, and complexity of the cellular endocytosis and trafficking pathways (1,2) leads to suboptimal magnitude and duration of pharmacological effects at the organelle of interest, as well as to non-specific effects due to exposure of additional organelles to the drug. Thus, attaining efficient and selective pharmacological effects for intracellularly acting drugs requires development of specialized drug delivery systems (DDS) that should be targeted to specific organelle and deliver the drug in a controlled fashion (3,4).

For this purpose, particle or vesicle (liposome)-based DDS can be used, and intracellular targeting can be achieved by decorating the drug or the DDS with organelle-specific targeting moieties. This approach relies on recognition of these moieties by the endogenous...


anti-cancer vaccines intracellular trafficking organelle-specific drug delivery targeted drug delivery systems targeting efficiency and kinetics 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Pharmacology and School of PharmacyBen-Gurion University of the NegevBeer-ShevaIsrael

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