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Pharmaceutical Research

, Volume 27, Issue 11, pp 2509–2513 | Cite as

Application of Plant Viruses as Nano Drug Delivery Systems

  • Yupeng Ren
  • Sek Man Wong
  • Lee Yong Lim
Commentary

ABSTRACT

Nano-sized drug delivery systems based on virus-derived platforms have promising delivery and targeting efficiencies. To date, much of our understanding of these systems is obtained from studies of animal viruses. Application of plant viruses for drug delivery is in the nascent stage, but it is becoming apparent that plant viral particles can be engineered to possess novel properties to meet the unique requirements of targeted drug delivery. Chemical functionalization of a plant viral particle surface can impart stealth properties to prolong in vivo circulation half-life and/or targeting capability to direct drug delivery to diseased tissues. The amino acid sequence of the viral coat protein can be genetically manipulated to yield protein cages of specific chemistry and morphology, while the conformation of the protein cage can be directed, via the external environment, to disassemble, then reassemble in vitro to exchange native viral genomic material with exogenous cargo. The purpose of this commentary is to evaluate current literature to assess the potential of nano-scale plant-virus-based drug delivery systems for the targeted delivery of chemotherapeutic agents.

KEY WORDS

coat protein drug delivery plant virus protein cage 

ABBREVIATIONS

CP

coat protein

CCMV

Cowpea chlorotic mottle virus

CPMV

Cowpea mosaic virus

CMV

Cucumber Mosaic Virus

Dox

doxorubicin

HCRSV

Hibiscus chlorotic ringspot virus

mw

molecular weight

MTT

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

PEG

polyethylene glycol

PSA

polystyrenesulfonic acid

PC

protein cage

RCNMV

Red clover necrotic mosaic virus

TEG

tetraethylene glycol

TMV

Tobacco mosaic virus

Notes

ACKNOWLEDGEMENTS

This work was supported by the ARF grants R-148-000-045-112 and R-154-000-252-112 from the National University of Singapore (NUS).

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Shanghai Institute of Materia Medica,Chinese Academy of SciencesShanghaiChina
  2. 2.Department of Biological Sciences,National University of SingaporeSingaporeSingapore
  3. 3.Temasek Life Sciences LaboratorySingaporeSingapore
  4. 4.Pharmacy Program School of Biomedical, Biomolecular and Chemical SciencesUniversity of Western Australia (M315)CrawleyAustralia

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