Pharmaceutical Research

, Volume 28, Issue 2, pp 292–300

Nanochannel Technology for Constant Delivery of Chemotherapeutics: Beyond Metronomic Administration

  • Alessandro Grattoni
  • Haifa Shen
  • Daniel Fine
  • Arturas Ziemys
  • Jaskaran S. Gill
  • Lee Hudson
  • Sharath Hosali
  • Randy Goodall
  • Xuewu Liu
  • Mauro Ferrari
Research Paper

ABSTRACT

Purpose

The purpose of this study is to demonstrate the long-term, controlled, zero-order release of low- and high-molecular weight chemotherapeutics through nanochannel membranes by exploiting the molecule-to-surface interactions presented by nanoconfinement.

Methods

Silicon membranes were produced with nanochannels of 5, 13 and 20 nm using standardized industrial microfabrication techniques. The study of the diffusion kinetics of interferonα-2b and leuprolide was performed by employing UV diffusion chambers. The released amount in the sink reservoir was monitored by UV absorbance.

Results

Continuous zero-order release was demonstrated for interferonα-2b and leuprolide at release rates of 20 and 100 μg/day, respectively. The release rates exhibited by these membranes were verified to be in ranges suitable for human therapeutic applications.

Conclusions

Our membranes potentially represent a viable nanotechnological approach for the controlled administration of chemotherapeutics intended to improve the therapeutic efficacy of treatment and reduce many of the side effects associated with conventional drug administration.

KEY WORDS

chemotherapy controlled release drug delivery implants nanochannel 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Alessandro Grattoni
    • 1
  • Haifa Shen
    • 1
  • Daniel Fine
    • 1
  • Arturas Ziemys
    • 1
  • Jaskaran S. Gill
    • 1
  • Lee Hudson
    • 2
  • Sharath Hosali
    • 2
  • Randy Goodall
    • 2
  • Xuewu Liu
    • 1
  • Mauro Ferrari
    • 1
    • 3
    • 4
    • 5
  1. 1.Department of NanoMedicine and Biomedical Engineering (nBME)The University of Texas Medical School at HoustonHoustonUSA
  2. 2.NanoMedical Systems, Inc.AustinUSA
  3. 3.Department of Experimental TherapeuticsThe University of Texas M.D. Anderson Cancer CenterHoustonUSA
  4. 4.Department of BioengineeringRice UniversityHoustonUSA
  5. 5.HoustonUSA

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