Pharmaceutical Research

, Volume 27, Issue 9, pp 1759–1771 | Cite as

Nanoparticle-Mediated Brain-Specific Drug Delivery, Imaging, and Diagnosis

Expert Review

ABSTRACT

Central nervous system (CNS) diseases represent the largest and fastest-growing area of unmet medical need. Nanotechnology plays a unique instrumental role in the revolutionary development of brain-specific drug delivery, imaging, and diagnosis. With the aid of nanoparticles of high specificity and multifunctionality, such as dendrimers and quantum dots, therapeutics, imaging agents, and diagnostic molecules can be delivered to the brain across the blood-brain barrier (BBB), enabling considerable progress in the understanding, diagnosis, and treatment of CNS diseases. Nanoparticles used in the CNS for drug delivery, imaging, and diagnosis are reviewed, as well as their administration routes, toxicity, and routes to cross the BBB. Future directions and major challenges are outlined.

KEY WORDS

BBB diagnosis drug delivery imaging nanoparticles 

Notes

ACKNOWLEDGEMENTS

This work was supported by National Institutes of Health (R21NS063200).

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Biomedical Engineering School of EngineeringVirginia Commonwealth UniversityRichmondUSA

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