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Pharmaceutical Research

, Volume 26, Issue 7, pp 1701–1710 | Cite as

Creating Functional Vesicle Assemblies from Vesicles and Nanoparticles

  • Robert J. Mart
  • Kwan Ping Liem
  • Simon J. Webb
Research Paper

Abstract

Vesicles (liposomes) have been shown to be excellent vehicles for drug delivery, yet assemblies of vesicles (vesicle aggregates) have been used infrequently in this context. However vesicle assemblies have useful properties not available to individual vesicles; their size can cause localisation in specific tissues and they can incorporate more functionality than is possible with individual vesicles. This article reviews progress on controlling the properties of vesicle assemblies in vitro, applications of vesicle assemblies in vivo, and our recent creation of magnetic nanoparticle–vesicle assemblies. The latter assemblies contain vesicles crosslinked by coated Fe3O4 nanoparticles and this inclusion of magnetic functionality makes them magnetically responsive, potentially allowing magnetically-induced contents release. This article describes further studies on the in vitro formation of these magnetic nanoparticle–vesicle assemblies, including the effect of changing magnetic nanoparticle concentration, pH, adhesive lipid structure and bilayer composition. These investigations have led to the development of thermally-sensitive magnetic nanoparticle–vesicle assemblies that release encapsulated methotrexate on warming.

KEY WORDS

aggregation liposome magnetic nanoparticle magnetically responsive magnetoliposome 

Notes

Acknowledgements

This work was supported by the BBSRC (KPL) and the Leverhulme Trust (RJM).

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Robert J. Mart
    • 1
  • Kwan Ping Liem
    • 1
  • Simon J. Webb
    • 1
  1. 1.Manchester Interdisciplinary Biocentre and the School of ChemistryUniversity of ManchesterManchesterUK

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