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Pharmaceutical Research

, Volume 27, Issue 1, pp 72–81 | Cite as

The Application of Electrostatic Dry Powder Deposition Technology to Coat Drug-Eluting Stents

  • Ravi Kumar Nukala
  • Harikrishna Boyapally
  • Ian J. Slipper
  • Andy P. Mendham
  • Dennis DouroumisEmail author
Research Paper

Abstract

Purpose

A novel methodology has been introduced to effectively coat intravascular stents with sirolimus-loaded polymeric microparticles.

Methods

Dry powders of the microparticulate formulation, consisting of non-erodible polymers, were produced by a supercritical, aerosol, solvent extraction system (ASES). A design of experiment (DOE) approach was conducted on the independent variables, such as organic/CO2 phase volume ratio, polymer weight and stirring-rate, while regression analysis was utilized to interpret the influence of all operational parameters on the dependent variable of particle size. The dry powders, so formed, entered an electric field created by corona charging and were sprayed on the earthed metal stent. Furthermore, the thermal stability of sirolimus was investigated to define the optimum conditions for fusion to the metal surfaces.

Results

The electrostatic dry powder deposition technology (EDPDT) was used on the metal strut followed by fusion to produce uniform, reproducible and accurate coatings. The coated stents exhibited sustained release profiles over 25 days, similar to commercial products. EDPDT-coated stents displayed significant reduced platelet adhesion.

Conclusions

EDPDT appeared to be a robust accurate and reproducible technology to coat eluting stents.

Key Words

coating drug eluting stents electrostatic deposition platelet adhesion supercritical fluids 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ravi Kumar Nukala
    • 1
  • Harikrishna Boyapally
    • 1
  • Ian J. Slipper
    • 1
  • Andy P. Mendham
    • 1
  • Dennis Douroumis
    • 1
    Email author
  1. 1.University of Greenwich, School of ScienceKentUK

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