The Application of Electrostatic Dry Powder Deposition Technology to Coat Drug-Eluting Stents
- 330 Downloads
A novel methodology has been introduced to effectively coat intravascular stents with sirolimus-loaded polymeric microparticles.
Dry powders of the microparticulate formulation, consisting of non-erodible polymers, were produced by a supercritical, aerosol, solvent extraction system (ASES). A design of experiment (DOE) approach was conducted on the independent variables, such as organic/CO2 phase volume ratio, polymer weight and stirring-rate, while regression analysis was utilized to interpret the influence of all operational parameters on the dependent variable of particle size. The dry powders, so formed, entered an electric field created by corona charging and were sprayed on the earthed metal stent. Furthermore, the thermal stability of sirolimus was investigated to define the optimum conditions for fusion to the metal surfaces.
The electrostatic dry powder deposition technology (EDPDT) was used on the metal strut followed by fusion to produce uniform, reproducible and accurate coatings. The coated stents exhibited sustained release profiles over 25 days, similar to commercial products. EDPDT-coated stents displayed significant reduced platelet adhesion.
EDPDT appeared to be a robust accurate and reproducible technology to coat eluting stents.
Key Wordscoating drug eluting stents electrostatic deposition platelet adhesion supercritical fluids
- 3.Lally C, Kelly DJ, Prendergast PG. Stents. In: Akay M, editor. Encyclopedia of biomedical engineering. New Jersey: Willey; 2006. p. 1–10.Google Scholar
- 10.Whelan DM, van der Giessen WJ, Krabbendam SC, van Vliet EA, Verdouw PD, Serruys PW, et al. Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries. Heart Drug. 2000;83:338–45.Google Scholar
- 17.Kim TG, Lee H, Jang Y, Park TG. Controlled release of paclitaxel from heparinized metal stent fabricated by layer-by-layer assembly of polylysine and hyaluronic acid-g-poly(lactic-co-glycolic acid) micelles encapsulating paclitaxel. Biomacromolecules; 2009. (in press).Google Scholar
- 19.FDA patient safety news. http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/psn/printer.cfm?id=356 Importance of antiplatelet therapy with drug eluting stents. (assessed 09/03)
- 33.Thierry B, Merhi Y, Silver J, Tabrizian M. Biodegradable membrane-covered stent from chitosanbased polymersGoogle Scholar