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Pharmaceutical Research

, Volume 25, Issue 1, pp 242–245 | Cite as

A Novel Gas Phase Method for the Combined Synthesis and Coating of Pharmaceutical Particles

  • Janne Raula
  • Anna Lähde
  • Esko I. Kauppinen
Short Communication

Abstract

Purpose

A novel aerosol flow reactor method for the combined gas phase synthesis and coating of particles for drug delivery has been developed.

Materials and Methods

As an example, micron-sized salbutamol sulfate particles were produced via droplet-to-particle conversion and in-situ coated by the physical vapor deposition (PVD) of l-leucine vapor.

Results

During the deposition, l-leucine vapor crystallized on the surfaces of amorphous salbutamol particles. The size of l-leucine crystallites increased with increasing vapor concentration of l-leucine. The salbutamol particles with rough l-leucine surfaces exhibited good flowability enabling to them to be dispersed into air flow without the delivery aid of coarse lactose carriers.

Conclusions

The fraction of particles smaller than 5 micrometers varied between 0.35 and 0.48 when dispersed into 60 l/min air flow having a jet Reynolds number of 30700. When the coated fine particles were blended with lactose carriers, the fine particle fraction was as high as 90%. The l-leucine coating also improved the stability of salbutamol particles when stored at 45% relative humidity atmosphere.

Key words

aerosol coating evaporation gas phase deposition inhalation l-leucine pharmaceutical powder production salbutamol sulfate surface modification vapor 

Notes

Acknowledgements

Financial support from the Finnish Academy is gratefully acknowledged. We thank Dr. Hua Jiang for the TEM analysis and Mr. Raoul Järvinen for assistance in building the experimental set-up.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.NanoMaterials Group, Laboratory of Physics & Center for New MaterialsHelsinki University of TechnologyEspooFinland
  2. 2.VTT BiotechnologyEspooFinland

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