Pharmaceutical Research

, Volume 23, Issue 7, pp 1417–1450 | Cite as

Nanotechnology: Intelligent Design to Treat Complex Disease

  • Patrick Couvreur
  • Christine Vauthier
Expert Review


The purpose of this expert review is to discuss the impact of nanotechnology in the treatment of the major health threats including cancer, infections, metabolic diseases, autoimmune diseases, and inflammations. Indeed, during the past 30 years, the explosive growth of nanotechnology has burst into challenging innovations in pharmacology, the main input being the ability to perform temporal and spatial site-specific delivery. This has led to some marketed compounds through the last decade. Although the introduction of nanotechnology obviously permitted to step over numerous milestones toward the development of the “magic bullet” proposed a century ago by the immunologist Paul Ehrlich, there are, however, unresolved delivery problems to be still addressed. These scientific and technological locks are discussed along this review together with an analysis of the current situation concerning the industrial development.

Key Words

autoimmune disease cancer drug targeting infections industrial development liposome metabolic disease nanoparticle vaccine nanotechnology 


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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  1. 1.Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612Université de Paris SudChatenay-Malabry CedexFrance

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