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Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Formation of inclusion complexes from disulfiram and hydroxypropyl-β-cyclodextrin was confirmed using x-ray diffraction, differential scanning calorimetry, and thermogravimetry followed by IR spectroscopy of the evolved gas mixture. Inclusion complexes were prepared in two ways using EtOH or distilled H2O as the solvent. Formation of an inclusion complex increased the thermal stability of disulfiram. Biological studies showed that the disulfiram inclusion complex was effective for preventing cataracts in OXYS rats.

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Acknowledgments

The experiments used equipment at the Common Use Center for Physical Research Methods at the A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, RAS.

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Authors and Affiliations

  1. MIREA – Russian Technological University, M. V. Lomonosov Institute of Fine Chemical Technology, 86 Prosp. Vernadskogo, Moscow, 119571, Russia

    V. S. Tyukova, S. A. Kedik, A. V. Panov & E. S. Zhavoronok

  2. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences (IPCS, RAS), 29 Leninskii Prosp, Moscow, 119991, Russia

    D. I. Mendeleev

  3. A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31/4 Leninskii Prosp, Moscow, 119071, Russia

    I. N. Senchikhin

  4. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 10 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090, Russia

    A. Zh. Fursova, Yu. V. Rumyantseva & N. G. Kolosova

  5. Novosibirsk Regional Clinical Hospital, 130 Nemirovicha-Danchenko, Novosibirsk, 630087, Russia

    A. Zh. Fursova

  6. Novosibirsk State University, 2 Pirogova St, Novosibirsk, 630090, Russia

    N. G. Kolosova

Authors
  1. V. S. Tyukova
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  2. S. A. Kedik
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  3. A. V. Panov
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  4. E. S. Zhavoronok
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  5. D. I. Mendeleev
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  6. I. N. Senchikhin
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  7. A. Zh. Fursova
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  8. Yu. V. Rumyantseva
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  9. N. G. Kolosova
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Corresponding author

Correspondence to E. S. Zhavoronok.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 12, pp. 31 – 37, December, 2019.

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Tyukova, V.S., Kedik, S.A., Panov, A.V. et al. Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats. Pharm Chem J 53, 1158–1163 (2020). https://doi.org/10.1007/s11094-020-02140-y

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  • DOI: https://doi.org/10.1007/s11094-020-02140-y

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