Skip to main content
SpringerLink
Log in

Method Development for Quantitative Determination of the Gaba Derivative Solifen

  • STRUCTURE OF CHEMICAL COMPOUNDS, METHODS OF ANALYSIS AND PROCESS CONTROL
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

An HPLC method for quantitative determination of the new biologically active GABA derivative Solifen was developed. The method sensitivity, compound retention time and UV absorption maximum were determined. The optimum extractant for the compound from biological samples was determined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

References

  1. N. N. Karkishchenko, V. V. Khoron'ko, and S. A. Sergeeva, Pharmacokinetics [in Russian], Feniks, Rostov-on-Don (2001).

  2. M. V. Karlina, O. N. Pozharitskaya, V. M. Kosman, et al., Eksp. Klin. Farmakol., 73(8), 46 – 48 (2010).

    CAS  PubMed  Google Scholar 

  3. V. P. Zherdev, S. S. Boiko, N. V. Mesonzhnik, et al., Eksp. Klin. Farmakol., 72(3), 16 – 21 (2009).

    CAS  PubMed  Google Scholar 

  4. I. N. Tyurenkov, V. N. Perfilova, and T. A. Popova, Byull. Eksp. Biol. Med., 155(3), 340 – 343 (2013).

    Article  Google Scholar 

  5. L. B. Ivanova, V. I. Karamysheva, V. N. Perfilova, et al., Probl. Reprod., 18(1), 28 – 30 (2012).

    CAS  Google Scholar 

  6. I. N. Tyurenkov, V. N. Perfilova, L. A. Smirnova, et al., Khim.-farm. Zh., 47(3), 55 – 56 (2013); Pharm. Chem. J., 47(3), 179 – 180 (20130.

  7. I. N. Tyurenkov, V. N. Perfilova, L. A. Smirnova, et al., Khim.-farm. Zh., 44(12), 68 – 70 (2010); Pharm. Chem. J., 44(12), 702 – 704 (2013).

  8. Guideline on Bioanalytical Method Validation (EMEA 2012); http://www.ema.europa.eu.

Download references

Author information

Authors and Affiliations

  1. Volgograd State Medical University, 1 Pavshikh Bortsov Sq, Volgograd, 400131, Russia

    L. A. Smirnova, A. F. Ryabukha, K. A. Kuznetsov, M. V. Velikopol’skaya, V. N. Perfilova, I. N. Tyurenkov & L. M. Ganicheva

  2. Volgograd Medical Science Center, 1 Pavshikh Bortsov Sq, Volgograd, 400131, Russia

    L. A. Smirnova, A. F. Ryabukha & K. A. Kuznetsov

  3. A. I. Herzen State Pedagogical University of Russia, 48 Nab. R. Moiki, St. Petersburg, 191186, Russia

    O. S. Vasil’eva

Authors
  1. L. A. Smirnova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. F. Ryabukha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. A. Kuznetsov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. V. Velikopol’skaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. N. Perfilova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. O. S. Vasil’eva
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I. N. Tyurenkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. L. M. Ganicheva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. A. Smirnova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 11, pp. 62 – 64, November, 2019.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Smirnova, L.A., Ryabukha, A.F., Kuznetsov, K.A. et al. Method Development for Quantitative Determination of the Gaba Derivative Solifen. Pharm Chem J 53, 1090–1092 (2020). https://doi.org/10.1007/s11094-020-02128-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-020-02128-8

Keywords

Search

Navigation