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Development of a Parenteral Medicinal Formulation of the New Antifungal Semisynthetic Polyene Antibiotic Amphamide

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The search for new antifungal agents with improved chemotherapeutic properties has produced the semisynthetic polyene macrolide amphotericin B derivative amphamide, which has a number of clear advantages over the starting antibiotic. The development of a medicinal formulation of amphamide for parenteral use is described, with high water solubility, good stability of the active ingredient, and high specific activity. The prototype composition has potential for a further full-scale set of clinical trials.

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Correspondence to A. N. Tevyashova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 10, pp. 50 – 53, October, 2019.

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Tevyashova, A.N., Bychkova, E.N., Solov’eva, S.E. et al. Development of a Parenteral Medicinal Formulation of the New Antifungal Semisynthetic Polyene Antibiotic Amphamide. Pharm Chem J (2020) doi:10.1007/s11094-020-02108-y

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Keywords

  • polyene antibiotics
  • amphamide
  • medicinal formulation
  • antifungal activity
  • stability