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Synthesis and Antibacterial and Antifungal Activity of 3-(Azol-1-Yl)-6-R-1,2,4,5-Tetrazines

  • R. I. IshmetovaEmail author
  • N. A. Gerasimova
  • N. P. Evstigneeva
  • I. A. Belyaninova
  • N. K. Ignatenko
  • A. A. Mukhina
  • N. V. Zil’berberg
  • N. V. Kungurov
  • G. L. Rusinov
  • O. N. Chupakhin
  • V. N. Charushin
Article
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Nucleophilic substitution and 1,3-dipolar cycloaddition reactions were used to synthesize 3,6-disubstituted derivatives of simm-tetrazine containing azolyl, aminoalkyl, and oxyalkyl fragments. The antibacterial activity of the resulting compounds was studied using the obligate pathogen Neisseria gonorrhoeae and opportunistic pathogenic microorganisms, while antifungal activity was assessed using anthropo- and zooanthropophilic dermatophytes.

Keywords

1,2,4,5-tetrazines nucleophilic substitution 1,3-dipolar cycloaddition antibacterial and antifungal activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • R. I. Ishmetova
    • 1
    Email author
  • N. A. Gerasimova
    • 2
  • N. P. Evstigneeva
    • 2
  • I. A. Belyaninova
    • 1
  • N. K. Ignatenko
    • 1
  • A. A. Mukhina
    • 3
  • N. V. Zil’berberg
    • 2
  • N. V. Kungurov
    • 2
  • G. L. Rusinov
    • 1
    • 3
  • O. N. Chupakhin
    • 1
    • 3
  • V. N. Charushin
    • 1
    • 3
  1. 1.I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of SciencesEkaterinburgRussia
  2. 2.Sverdlovsk Regional Urals Science Research Institute of Dermatoneurology and ImmunopathologyEkaterinburgRussia
  3. 3.First President of Russian B. N. Eltsin Urals Federal UniversityEkaterinburgRussia

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