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Synthesis and Antiglycating Activity of 2-Aminopropylmorpholino-5-Aryl-6H-1,3,4-Thiadiazine Dihydrobromides and 2-Aminopropylmopholino-5-Thienyl-6H-1,3,4-Thiadiazine Dihydrobromides

  • T. A. TseitlerEmail author
  • L. P. Sidorova
  • V. V. Emel’yanov
  • E. A. Savateeva
  • O. N. Chupakhin
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A group of novel 2-propylmorpholino-5-aryl- and 5-thienyl-6H-1,3,4-thiadiazine dihydrobromides was synthesized by cyclocondensation of 4-[3-(4-morpholino)propyl]-3-thiosemicarbazide with α –haloacetoarenones or α-haloacetylthiophenones. Two compounds of this group were found to produce effective inhibition of non-enzymatic protein glycation in an in vitro model system. These test results indicate that compounds IIIa and IIIc, which contain phenyl- and 4′ -chlorophenyl groups at position 5 of the thiadiazine ring respectively, are candidates for in vivo studies.

Keywords

1,3,4-thiadiazine cyclocondensation α-haloacetophenones α-haloacetylthiophenones non-enzymatic protein glycation 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • T. A. Tseitler
    • 1
    • 2
    Email author
  • L. P. Sidorova
    • 1
  • V. V. Emel’yanov
    • 1
  • E. A. Savateeva
    • 1
  • O. N. Chupakhin
    • 1
    • 2
  1. 1.Urals First President of Russian B. N. Yeltsin Federal UniversityEkaterinburgRussia
  2. 2.I. Ya. Postovskii Institute of Organic SynthesisUrals Branch, Russian Academy of SciencesEkaterinburgRussia

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