Chemoprevention of Radiation-Induced Carcinogenesis Using Decoction of Meadowsweet (Filipendula Ulmaria) Flowers
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The ability of the decoction of meadowsweet flowers (Filipendula ulmaria, FU) to inhibit tumor development in female LIO rats was demonstrated using a radiation-induced carcinogenesis model (single γ-radiation dose of 4 Gy). Over half of tumors that developed in various locations in most (79.6%) irradiated control rats were malignant. The tumors were most often located in the breast. The carcinogenesis parameters for all locations (multiplicity of all tumors and incidence of malignant tumors) and especially for breast tumors (number of tumor-bearing rats, multiplicity of all and only malignant tumors) were reduced considerably in irradiated rats that received FU with drinking water over 16 months.
Keywordsmeadowsweet Filipendula ulmaria cancer chemoprevention radiation carcinogenesis
The work was performed using state financial support for leading universities of the Russian Federation (Grant RFMEFI58117X0020).
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