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Pharmaceutical Chemistry Journal

, Volume 52, Issue 10, pp 839–843 | Cite as

Synthesis and Neurotropic Activity of 4-Phenylpyridine-3-Carboxylic Acid and 3-Hydroxy-4-Phenylthieno[2,3-b]-Pyridine Derivatives

  • E. G. Paronikyan
  • A. V. OgannisyanEmail author
  • R. G. Paronikyan
  • I. A. Dzhagatspanyan
  • I. M. Nazaryan
  • A. G. Akopyan
  • N. S. Minasyan
Article
  • 33 Downloads

Aseries of pyridine-3-carboxylic acid derivatives were synthesized via recyclization of a thiopyran ring using cyclic secondary amines and then converted into substituted thieno[2,3-b]pyridines. Studies of the neurotropic properties identified several synthesized compounds with anticonvulsant activity against corazole-induced seizures. The compounds were active as psychological sedatives and, in contrast with the tranquilizer diazepam, were inactive as central myorelaxants at anticonvulsant doses.

Keywords

pyridine-3-carboxylic acid derivatives thieno[2,3-b]pyridines neurotropic activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. G. Paronikyan
    • 1
  • A. V. Ogannisyan
    • 1
    Email author
  • R. G. Paronikyan
    • 1
  • I. A. Dzhagatspanyan
    • 1
  • I. M. Nazaryan
    • 1
  • A. G. Akopyan
    • 1
  • N. S. Minasyan
    • 2
  1. 1.A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of Armenia0014 YerevanArmenia
  2. 2.Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of Armenia0014 YerevanArmenia

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