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Pharmaceutical Chemistry Journal

, Volume 52, Issue 10, pp 835–838 | Cite as

Radioprotective Efficiency of Recombinant Flagellin and Interleukin-1 Beta with Combined Administration

  • E. V. Murzina
  • G. A. Sofronov
  • A. S. Simbirtsev
  • A. M. Ishchenko
  • T. O. Antipova
  • N. V. Aksenova
  • O. M. Veselova
  • V. V. Zatsepin
Article
  • 30 Downloads

The radioprotective efficacy of recombinant flagellin (FL) and interleukin-1 beta (IL-1) administered in combinations for preventive or therapeutic purposes was studied in experiments on white mongrel mice. The drugs were administered i.p. at doses of 1 mg/kg (FL) and 50 μg/kg (IL-1β). Simultaneous administration of the drugs in the early stages before irradiation was shown to be most efficacious in terms of 30-day survival of mice exposed to x-rays at a dose of 7.5 Gy (100% survival of mice vs. 53% survival in the control group, p < 0.01). Sequential administration of FL before exposure and IL-1β after exposure increased survival of the mice by 40% (p < 0.05). The results indicated that combined use of biotechnological drugs for radioprotection was promising.

Keywords

flagellin combined use interleukin-1 beta exposure survival 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. V. Murzina
    • 1
  • G. A. Sofronov
    • 1
    • 2
  • A. S. Simbirtsev
    • 2
    • 3
  • A. M. Ishchenko
    • 3
  • T. O. Antipova
    • 3
  • N. V. Aksenova
    • 1
  • O. M. Veselova
    • 1
  • V. V. Zatsepin
    • 1
  1. 1.S. M. Kirov Military Medical AcademyMinistry of Defense of the RFSt. PetersburgRussia
  2. 2.Institute of Experimental MedicineRussian Academy of Medical SciencesSt. PetersburgRussia
  3. 3.Research Institute of Highly Pure Biopreparations, Federal Medical-Biological AgencySt. PetersburgRussia

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