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Pharmaceutical Chemistry Journal

, Volume 53, Issue 7, pp 650–654 | Cite as

Analgesic and Anti-Inflammatory Activity of Vanillin Derivatives

  • Yu. A. Boiko
  • M. V. NesterkinaEmail author
  • A. A. Shandra
  • I. A. Kravchenko
Article
  • 2 Downloads

The analgesic activity of 4-hydroxy-3-methoxybenzaldehyde (vanillin) derivatives with different pharmacophore groups were studied in vivo in models of chemically induced pain induced by subplantar administration of the TRP ion channel agonists capsaicin and allylisothiocyanate. The anti-inflammatory actions of vanillin derivatives were demonstrated in a model of carrageenan-induced edema. The analgesic and anti-inflammatory activities of vanillin and its derivatives were studied; these are linked with the effects of these substances on TRPA1 and TRPV1 receptors.

Keywords

Vanillin derivatives TRPA1 and TRPV1 receptors analgesic activity anti-inflammatory activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yu. A. Boiko
    • 1
  • M. V. Nesterkina
    • 2
    • 3
    Email author
  • A. A. Shandra
    • 1
  • I. A. Kravchenko
    • 2
    • 3
  1. 1.Odessa National Medical UniversityOdessaUkraine
  2. 2.Odessa National Polytechnic UniversityOdessaUkraine
  3. 3.I. I. Mechnikov Odessa National UniversityOdessaUkraine

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