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Pharmaceutical Chemistry Journal

, Volume 53, Issue 7, pp 624–627 | Cite as

Dinitrodibenzo [B,D]Oxepin-7(6h)-One Antiproliferative Activity Against Hepg2 Cells

  • Qiang Li
  • ShaoPing Sun
  • XianFeng GongEmail author
Article
  • 4 Downloads

The cytotoxic activity of twenty three new biphenyl compounds was investigated, and the IC50 value of 1,2-dinitrodibenzo [b,d]oxepin-7(6H)-one (DNDBO) was found to be the lowest among these compounds. The underlying mechanism of DNDBO-induced cell death was explored.

Keywords

biphenyl compounds cytotoxic activity HepG2 cells 

References

  1. 1.
    J. Wu, J. B. Hou, M. M. Zhang, et al., Transplant. Proc., 40, 3719 – 3722 (2008).Google Scholar
  2. 2.
    J. Hu., X. L. Yan, W. Wang, et al., Tsinghua Sci. Tech.,13, 474 – 479 (2008).Google Scholar
  3. 3.
    V. L. Niranjan Reddy, V. Ravikanth, V. V. Jansi Lakshmi, et al., Fitoterapia, 74, 600 – 602 (2003).CrossRefGoogle Scholar
  4. 4.
    Y. K. Li, Z. Y. Wang, X. X. Wu, et al., Phytochem. Lett., 11, 24 – 27 (2015).Google Scholar
  5. 5.
    M. Zhou, K. Zhou, J. Lou, et al., Phytochem. Lett., 14, 226 – 229 (2015).Google Scholar
  6. 6.
    M. Sánchez-Peris, E. Falomir, J. Murga, et al., Bioorg. Med. Chem., 24, 3108 – 3115 (2016)Google Scholar
  7. 7.
    C. S. Kim, L. Subedi, O. K. Kwon, et al., Bioorg Med Chem Lett., 26, 351 – 354 (2016).Google Scholar
  8. 8.
    Q. F. Hu, Y. D. Wang, D. L. Zhu, et al., J. Asian Nat. Prod. Res. DOI: 10.1080 / 10286020.2016.1193490Google Scholar
  9. 9.
    Y. Liu, C. Lei, X. Y. Xu, et al., Chin. Chem. Lett., 27, 321 – 324 (2016).Google Scholar
  10. 10.
    L. A. Torre, F. Bray, R. L. Siegel, et al., CA. Cancer. J. Clin., 65(2), 87 – 108 (2015).Google Scholar
  11. 11.
    R. Z. Shi, H. W. Peng, X. F. Yuan, et al., J. Cell Biochem., 114, 1890 – 1900 (2013).Google Scholar
  12. 12.
    Y. H. Han, S. Z. Kim, S. H. Kim, et al., Chem.-Biol. Interact., 177, 107 – 114 (2009).Google Scholar
  13. 13.
    C. Lou, G. Yang, H. Cai, et al., Toxicol. in Vitro, 24, 1333 – 1337 (2010).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Heilongjiang UniversitySchool of Chemistry and Materials ScienceHarbinChina

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