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Pharmaceutical Chemistry Journal

, Volume 53, Issue 7, pp 620–623 | Cite as

Synthesis and Pharmacological Activity of S(-)-2-Amino-2-Methyl-3-Phenylpropanoic Acid

  • S. H. Grigoryan
  • A. G. Zhamharyan
  • A. S. Saghyan
  • A. A. Chitchiyan
  • L. S. Balyan
  • A. S. Poghosyan
  • H. V. Topchyan
  • M. G. BalasanyanEmail author
Article
  • 8 Downloads

Taking into account the high efficacy of 2-arylpropionic acid derivatives among NSAIDs and based on their SARs, we have evaluated the anti-inflammatory, antinociceptive, and antiaggregant activity and ulcerogenic properties of a new synthesized non-protein amino acid (NPAA) derivative S(-)-2-amino-2-methyl-3-phenylpropanoic acid (NPAA-36). A new method of NPAA-36 synthesis was developed and experiments were carried out, which showed that this compound injected in a dose of 10 mg/kg (i.p.) inhibited xylene-induced ear oedema by about 31.1%, which proved its anti-inflammatory properties. The antinociceptive activity of NPAA-36 was assessed in tail-flick test by the ability to increase the tail cut-off latency by 36.78% within 60 min after injection at the same dose. Investigation of the ulcerogenic properties of NPAA-36 demonstrated that it exhibited lower gastrointestinal toxicity than a well-known arylpropionic acid derivative NSAID. Results of in vitro experiments showed the antiplatelet activity registered not in all (only in 41.2%) cases, which might imply lower bleeding. The obtained data indicate that the new NPAAderivative can be a potential basis for the development of new anti-inflammatory drugs with weak side effects.

Keywords

non-protein amino acid anti-inflammatory activity ulcerogenic activity antinociceptive activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • S. H. Grigoryan
    • 1
  • A. G. Zhamharyan
    • 1
  • A. S. Saghyan
    • 2
  • A. A. Chitchiyan
    • 1
  • L. S. Balyan
    • 1
  • A. S. Poghosyan
    • 2
  • H. V. Topchyan
    • 1
  • M. G. Balasanyan
    • 1
    Email author
  1. 1.M. Heratsi Yerevan State Medical UniversityYerevanArmenia
  2. 2.Research and Production Center “Armbiotechnology”National Academy of Sciences of ArmeniaYerevanArmenia

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