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Pharmaceutical Chemistry Journal

, Volume 53, Issue 6, pp 495–499 | Cite as

Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines

  • S. N. SirakanyanEmail author
  • É. K. Akopyan
  • R. G. Paronikyan
  • I. M. Nazaryan
  • A. G. Akopyan
  • A. A. Ovakimyan
Article
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Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4-c]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of the compounds. The tested compounds displayed neurotropic activity. Several compounds of this series exhibited pronounced anticonvulsant and anxiolytic activity.

Keywords

disubstituted piperazine alkylation neurotropic activity anxiolytic activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • S. N. Sirakanyan
    • 1
    Email author
  • É. K. Akopyan
    • 1
  • R. G. Paronikyan
    • 1
  • I. M. Nazaryan
    • 1
  • A. G. Akopyan
    • 1
  • A. A. Ovakimyan
    • 1
  1. 1.A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of ArmeniaYerevanArmenia

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