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Iron-Binding and Iron-Reducing Properties of Material Based on Collagen and Taxifolin (Dihydroquercetin) Under Physiological and Pathophysiological Conditions

  • Yu. V. ShatalinEmail author
  • V. S. Shubina
DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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The properties of gels prepared from collagen and the natural polyphenol taxifolin were studied. The degradation rate of the gel was shown to decrease with increasing fraction of functionalized taxifolin in it. Gel including polyphenol exhibited iron(II)-binding and iron(III)-reducing activity whereas polyphenol released from the gel could reduce iron ions but did not exhibit significant iron-binding activity. Oxidative modification of the gel increased the polyphenol release rate and decreased its metal-binding properties. In general, the results suggested that stable gels could be produced from collagen and taxifolin and could exhibit antioxidant activity by binding iron ions.

Keywords

taxifolin collagen degradation iron-binding activity oxidative stress 

Notes

Acknowledgments

The work was financially supported by the RFBR No. 15-04-02377 and used equipment at the CUC, ITEB, RAS.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences (ITEB RAS)MoscowRussia
  2. 2.Pushchino State Institute of Natural SciencesMoscowRussia

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